{"id":"W4210847582","doi":"10.21203/rs.3.rs-1289285/v1","title":"Neuro Protective Effect of Baicalein Against Oxaliplatin-Induced Peripheral Neuropathy: Impact on Oxidative Stress, Neuro-inflammation and WNT/β-Catenin Signaling","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Pharmaceutical Education and Research, Raebareli","keywords":"Baicalein; Oxidative stress; Oxaliplatin; Inflammation; Peripheral neuropathy; Wnt signaling pathway; Medicine; Catenin; Pharmacology; Immunology; Signal transduction; Internal medicine; Biology; Cell biology; Endocrinology; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006220875,0.0003266185,0.0004444418,0.000159745,0.0001689098,0.000201185,0.0001230612,0.0002330252,0.002650572],"category_scores_gemma":[0.00009906758,0.00007836357,0.0002039669,0.000153752,0.0001703615,0.0002474265,0.000128466,0.0005665044,0.0001979285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000262518,"about_ca_system_score_gemma":0.0004408977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001698132,"about_ca_topic_score_gemma":0.003491301,"domain_scores_codex":[0.9999654,0.000003058858,0.000002140234,0.000008316454,0.000006510706,0.00001445742],"domain_scores_gemma":[0.9999765,0.000002020079,0.000005420652,0.000001818769,0.000003183132,0.00001104806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007629226,0.0003586075,0.0004320095,0.0004644724,0.00006442459,0.0001553038,0.00003956496,0.0001681932,0.9781838,0.0003155914,0.0007818833,0.01140703],"study_design_scores_gemma":[0.001040201,0.003551411,0.01753698,0.00005102525,0.0001866305,0.0004208355,0.00008994598,0.001202305,0.9684628,0.0002254253,0.007209045,0.00002329876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909042,0.004859141,0.0006562314,0.0003153305,0.0001477984,0.00005321051,0.0007758844,0.000105281,0.002182902],"genre_scores_gemma":[0.9935048,0.002087758,0.0009454662,0.00008341355,0.00002409108,0.00004685064,0.0005078331,0.00001540759,0.002784414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002650572,"threshold_uncertainty_score":0.008867025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05062817158793939,"score_gpt":0.4159983247780883,"score_spread":0.365370153190149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}