{"id":"W4210850048","doi":"10.3389/fonc.2022.812598","title":"Blockade of Uttroside B-Induced Autophagic Pro-Survival Signals Augments Its Chemotherapeutic Efficacy Against Hepatocellular Carcinoma","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science and Engineering Research Board; Department of Science and Technology, Ministry of Science and Technology, India","keywords":"Autophagy; Hepatocellular carcinoma; Apoptosis; Bafilomycin; Cancer research; Cancer cell; Medicine; Pharmacology; Blockade; Cancer; Liver cancer; Drug; Chemistry; Internal medicine; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008020823,0.0003586869,0.0003898227,0.0003884399,0.000179823,0.000167303,0.0001440248,0.0001978283,0.001816093],"category_scores_gemma":[0.0000784061,0.00008230425,0.0002435231,0.0002141702,0.0001759867,0.000177624,0.0001841693,0.0005900431,0.0003473946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001342962,"about_ca_system_score_gemma":0.0002051614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004261183,"about_ca_topic_score_gemma":0.0007357713,"domain_scores_codex":[0.9999436,0.00001302779,0.000005631844,0.000006289503,0.00001037448,0.00002105564],"domain_scores_gemma":[0.9999497,0.000007627755,0.000008591129,0.000007282926,0.000005986237,0.00002085216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000567462,0.0002522785,0.0001469654,0.0001481645,0.00001262276,0.0001112059,0.00002055926,0.0001377525,0.9915529,0.00009169016,0.0001604248,0.006797988],"study_design_scores_gemma":[0.0001424362,0.003189834,0.004734455,0.00001756746,0.00004048075,0.0003156306,0.00003425212,0.001029939,0.9864448,0.00006398797,0.003975745,0.00001097249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914644,0.003839757,0.001227762,0.0001740009,0.00006813103,0.00007376317,0.0002378444,0.0001488587,0.002765577],"genre_scores_gemma":[0.9955992,0.002032275,0.0008854322,0.00009184123,0.00002201183,0.00005056278,0.000255422,0.00001049632,0.001052824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001816093,"threshold_uncertainty_score":0.006075442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03795122370374698,"score_gpt":0.3081777791002874,"score_spread":0.2702265553965404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}