{"id":"W4210850500","doi":"10.1172/jci.insight.157342","title":"Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection","year":2022,"lang":"en","type":"review","venue":"JCI Insight","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Weill Cornell Medical College; National Cancer Institute; Peking Union Medical College; National Institutes of Health; Chinese Academy of Medical Sciences; Cold Spring Harbor Laboratory; Deutsche Forschungsgemeinschaft; York University; Pershing Square Foundation; College of Veterinary Medicine, Cornell University; Cancer Research Institute","keywords":"Neutrophil extracellular traps; Medicine; Lung; Disulfiram; Context (archaeology); Drug; Immunology; Acute kidney injury; Pharmacology; Immune system; Inflammation; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002603507,0.0005682823,0.0006441925,0.0009930686,0.0001583941,0.0004135522,0.0004768008,0.000584322,0.001878103],"category_scores_gemma":[0.000280308,0.0001845984,0.0003772202,0.0004965367,0.0002052169,0.0004035914,0.0002753789,0.001444256,0.001360041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003696316,"about_ca_system_score_gemma":0.0004397727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030322,"about_ca_topic_score_gemma":0.002982928,"domain_scores_codex":[0.9999124,0.00001308753,0.00001029415,0.000009950241,0.00004316355,0.00001116034],"domain_scores_gemma":[0.9999198,0.00001517161,0.00001373154,0.000002920283,0.00003258813,0.00001589947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003163101,0.0002119057,0.0003267161,0.007538023,0.0002006757,0.0001981111,0.00004619768,0.000394783,0.01690523,0.002491921,0.04477742,0.9265927],"study_design_scores_gemma":[0.0001472467,0.0005179574,0.002903912,0.001029818,0.0001833951,0.0009219255,0.00003590635,0.000271902,0.006091693,0.0009625516,0.9869086,0.00002503834],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002019081,0.9920922,0.0003972586,0.0006869511,0.0004718764,0.00002591781,0.0001004987,0.00005484394,0.004151364],"genre_scores_gemma":[0.006692618,0.9880703,0.0004795751,0.0004458302,0.0001914454,0.000022686,0.0001820658,0.00000530661,0.003910195],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001878103,"threshold_uncertainty_score":0.006282926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04307534770724261,"score_gpt":0.2973296976102713,"score_spread":0.2542543499030286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}