{"id":"W4210863439","doi":"10.4155/bio-2022-0010","title":"Recommendations on ELISpot Assay Validation by the GCC","year":2022,"lang":"en","type":"article","venue":"Bioanalysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Grand Challenges Canada; Caprion (Canada)","funders":"","keywords":"ELISPOT; Immunity; Immunology; Medicine; Computational biology; Biology; Immune system; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1060703,0.003062603,0.002495988,0.0107659,0.00274322,0.006892905,0.01039313,0.01846904,0.01003738],"category_scores_gemma":[0.1210494,0.003015712,0.004802785,0.004652614,0.004878826,0.003867873,0.004697547,0.01382509,0.02537281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003123476,"about_ca_system_score_gemma":0.01538753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009174472,"about_ca_topic_score_gemma":0.008362071,"domain_scores_codex":[0.8888925,0.04792352,0.01266085,0.004244627,0.04248535,0.003793322],"domain_scores_gemma":[0.7994913,0.06821474,0.009664674,0.012657,0.1055892,0.004382982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00076154,0.0006577647,0.004196929,0.006363332,0.0001556912,0.001180943,0.001698628,0.002025962,0.03428729,0.02088688,0.6357862,0.2919988],"study_design_scores_gemma":[0.000106685,0.0002930986,0.002778193,0.007535116,0.0001598807,0.0009261972,0.0005655057,0.0007879725,0.02321528,0.007180407,0.9563,0.0001517483],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01372457,0.0919021,0.289334,0.2352303,0.04455676,0.01275379,0.01669708,0.01355544,0.2822461],"genre_scores_gemma":[0.03222023,0.05936082,0.5878362,0.1669004,0.005718916,0.01430407,0.02177914,0.003257603,0.1086226],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1060703,"threshold_uncertainty_score":0.5609603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03087585282540766,"score_gpt":0.2956638180288257,"score_spread":0.264787965203418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}