{"id":"W4210864710","doi":"10.1172/jci.insight.141289","title":"Immunoglobulin A nephropathy is characterized by anticommensal humoral immune responses","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Hospital for Sick Children; University of British Columbia; Mount Sinai Hospital; Health Sciences Centre; University Health Network; University of Toronto","funders":"Department of Medicine, University of Toronto; Canadian Institutes of Health Research; University of Toronto; Kidney Foundation of Canada; Omeros Corporation; Alnylam Pharmaceuticals; Pfizer","keywords":"Immunology; Immune system; Nephropathy; B-cell activating factor; Neisseria; Immunoglobulin A; ELISPOT; Medicine; Biology; Antibody; B cell; Immunoglobulin G; T cell; Endocrinology; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002421324,0.0004889675,0.0003299935,0.0007008884,0.0003659638,0.0003696057,0.0002283801,0.0006335742,0.001954016],"category_scores_gemma":[0.0002765254,0.0001151187,0.0002540656,0.0005302487,0.000439268,0.000218523,0.0003607394,0.0004849792,0.0004644345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003115239,"about_ca_system_score_gemma":0.0003003245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009160239,"about_ca_topic_score_gemma":0.0007456206,"domain_scores_codex":[0.9997383,0.00004757869,0.00002843721,0.0000663617,0.00006715035,0.00005217321],"domain_scores_gemma":[0.999817,0.00002343892,0.00007624237,0.00001406346,0.00002321536,0.00004603042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001471937,0.0005562614,0.0787635,0.0008002265,0.0002222833,0.01425797,0.0002750933,0.0002021058,0.8236,0.003204039,0.002849033,0.07379759],"study_design_scores_gemma":[0.0002443253,0.002830297,0.6036195,0.000336914,0.0004256414,0.1321324,0.0004248975,0.001972829,0.1572843,0.005814043,0.09484204,0.00007289022],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9558856,0.01350765,0.007629178,0.0006795703,0.000230098,0.0001256059,0.0005950921,0.0005349459,0.02081231],"genre_scores_gemma":[0.989581,0.003817623,0.001790184,0.0006250163,0.0001200624,0.00003996445,0.000466513,0.00003545663,0.003524101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001954016,"threshold_uncertainty_score":0.006536841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150165347433108,"score_gpt":0.2635423655819467,"score_spread":0.2485258308386359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}