{"id":"W4210865723","doi":"10.3389/fmicb.2021.787726","title":"Endogenous CRISPR-Cas Systems in Group I Clostridium botulinum and Clostridium sporogenes Do Not Directly Target the Botulinum Neurotoxin Gene Cluster","year":2022,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Allergy and Infectious Diseases; Food and Drug Administration; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Clostridium sporogenes; Clostridium botulinum; CRISPR; Clostridium; Neurotoxin; Biology; Gene cluster; Microbiology; Gene; Genetics; Toxin; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000278726,0.0002892576,0.0003963766,0.0005856677,0.0003731776,0.0006925988,0.0002843723,0.0004295284,0.001687852],"category_scores_gemma":[0.0006667503,0.0002192929,0.0005169915,0.0007069134,0.0003432583,0.0002274668,0.0003124725,0.0005558798,0.0007456854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006827107,"about_ca_system_score_gemma":0.0004611062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002121803,"about_ca_topic_score_gemma":0.003254506,"domain_scores_codex":[0.9994844,0.00003252242,0.00004380922,0.0001418772,0.0002114583,0.00008578901],"domain_scores_gemma":[0.9996357,0.0001033459,0.0001322299,0.00003787869,0.00004507782,0.00004575966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002771744,0.00005000836,0.005766336,0.0004559894,0.00006870938,0.0002831961,0.0001017424,0.002078155,0.9725869,0.0005359176,0.0005273477,0.01726837],"study_design_scores_gemma":[0.00004432522,0.0006271515,0.09659332,0.00009152929,0.0002132059,0.002108843,0.0003696792,0.0178265,0.8528769,0.0007903637,0.02836257,0.00009556085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706575,0.001291437,0.01709235,0.0001575988,0.00003702289,0.00008514473,0.006048215,0.0008037913,0.003826872],"genre_scores_gemma":[0.9575318,0.0008228969,0.02903032,0.0002046607,0.000009016446,0.0001162847,0.008983301,0.0002374651,0.003064233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002121803,"threshold_uncertainty_score":0.005646408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397667418667785,"score_gpt":0.2202570895133075,"score_spread":0.2062804153266296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}