{"id":"W4210865723","doi":"10.3389/fmicb.2021.787726","title":"Endogenous CRISPR-Cas Systems in Group I Clostridium botulinum and Clostridium sporogenes Do Not Directly Target the Botulinum Neurotoxin Gene Cluster","year":2022,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Institute of Allergy and Infectious Diseases; Food and Drug Administration; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Clostridium sporogenes; Clostridium botulinum; CRISPR; Clostridium; Neurotoxin; Biology; Gene cluster; Microbiology; Gene; Genetics; Toxin; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009530811,0.000508262,0.001029018,0.0004223545,0.0003180777,0.00003770852,0.0004928586,0.0005050063,0.0001268888],"category_scores_gemma":[0.00011789,0.00038095,0.0002124854,0.0007096431,0.0005136923,0.0000576809,0.0005087309,0.001838916,0.00001608757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002125167,"about_ca_system_score_gemma":0.0001144418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002076679,"about_ca_topic_score_gemma":0.00002339874,"domain_scores_codex":[0.9955186,0.001227905,0.0009577041,0.001066841,0.0001851043,0.001043903],"domain_scores_gemma":[0.9987253,0.0002330498,0.0002536535,0.0005792335,0.00004086953,0.0001679054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005570686,0.001328873,0.1046058,0.0001950132,0.0003341495,0.002976034,0.00131213,0.002025088,0.8394093,0.0001135766,0.04067794,0.00145141],"study_design_scores_gemma":[0.03872943,0.008804412,0.02556432,0.0002003179,0.000734674,0.02357451,0.007339107,0.006539717,0.2021688,0.001420088,0.6814224,0.003502204],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549291,0.02998091,0.0003129945,0.006618543,0.004761458,0.002736207,0.0002626933,0.0001077135,0.0002903425],"genre_scores_gemma":[0.9894054,0.003039368,0.0007158762,0.005621027,0.0002017207,0.0003576289,0.0002308902,0.00008221758,0.0003458959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6407444,"threshold_uncertainty_score":0.9998642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397667418667785,"score_gpt":0.2202570895133075,"score_spread":0.2062804153266296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}