{"id":"W4210871538","doi":"10.1016/j.tetlet.2022.153677","title":"Total synthesis of the macrocyclic peptide stylopeptide II using oxime resin","year":2022,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"PROTEO; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Oxime; Epimer; Sponge; Peptide; Stereochemistry; Combinatorial chemistry; Peptide synthesis; Total synthesis; Organic chemistry; Biochemistry; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009101,0.0005102978,0.0003593401,0.0002021878,0.0001920789,0.0002302554,0.0002672363,0.0001717362,0.002692846],"category_scores_gemma":[0.00008497708,0.0001592881,0.0002438498,0.0002069932,0.0001371166,0.0002033316,0.0003030436,0.0004264149,0.001459705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001502224,"about_ca_system_score_gemma":0.0003451418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003642107,"about_ca_topic_score_gemma":0.0005057906,"domain_scores_codex":[0.999917,0.000007754511,0.000005365914,0.00001994508,0.00001900313,0.00003090905],"domain_scores_gemma":[0.9999448,0.000006366599,0.00000951647,0.000008526084,0.000009611536,0.00002106442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001231231,0.00001593917,0.00009137575,0.00008817321,0.000009366071,0.0002158857,0.00005314511,0.0002456577,0.9907099,0.000365175,0.0001636157,0.007918655],"study_design_scores_gemma":[0.0000167705,0.0003635867,0.0007157564,0.000007923266,0.00002194517,0.0002412773,0.00002647219,0.0003460099,0.9894867,0.0001058575,0.008655983,0.00001173053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9146875,0.00295202,0.0589817,0.0001518423,0.0001437063,0.0003065372,0.002297747,0.0006919649,0.01978703],"genre_scores_gemma":[0.9507096,0.002429896,0.02514307,0.0001056692,0.00003323687,0.0001634926,0.001902734,0.0001719453,0.01934048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002692846,"threshold_uncertainty_score":0.009008467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007166989944517326,"score_gpt":0.2117704774646474,"score_spread":0.20460348752013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}