{"id":"W4210875640","doi":"10.1161/circgen.121.003489","title":"Genome-Wide Characterization of a Highly Penetrant Form of Hyperlipoprotein(a)emia Associated With Genetically Elevated Cardiovascular Risk","year":2022,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"Agence Nationale de la Recherche","keywords":"Penetrant (biochemical); Locus (genetics); Phenotype; Disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002326845,0.0002155193,0.0009800023,0.0002811376,0.000201479,0.00000487271,0.0001115815,0.0001095217,0.0002571358],"category_scores_gemma":[0.0002834289,0.0001690601,0.0002422269,0.0005419511,0.0001526375,0.00005373983,0.0000707853,0.0002832784,0.000001090361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743889,"about_ca_system_score_gemma":0.0002116805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001642923,"about_ca_topic_score_gemma":0.000003188184,"domain_scores_codex":[0.9969869,0.0003289337,0.0008219841,0.0004306358,0.001191718,0.0002398591],"domain_scores_gemma":[0.9981894,0.0001101082,0.0004962548,0.0006561233,0.0003680481,0.0001800708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001494959,0.0002646973,0.1454031,0.0004667196,0.002682078,0.00003501951,0.002314155,0.002745726,0.7395239,0.00008938169,0.000007991307,0.1049722],"study_design_scores_gemma":[0.005021662,0.001210862,0.9867199,0.0001716545,0.001067171,0.00008050445,0.0001387136,0.001547514,0.001836348,0.0001442721,0.001887619,0.0001737814],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792912,0.003531731,0.01520727,0.0001251728,0.00008633007,0.001545751,0.00006407537,0.00003150519,0.0001169959],"genre_scores_gemma":[0.9975887,0.001139152,0.0003268363,0.00009563808,0.0001203898,0.00007044485,0.0005664231,0.0000423405,0.00005010845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8413168,"threshold_uncertainty_score":0.6894072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188599792172185,"score_gpt":0.2133148128723044,"score_spread":0.2014288149505826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}