{"id":"W4210880127","doi":"10.1002/ange.202112931","title":"A Kinetic and Fluorogenic Enhancement Strategy for Labeling of Nucleic Acids","year":2022,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioorthogonal chemistry; Tetrazine; Nucleic acid; Intercalation (chemistry); Acridine; Chemistry; Quenching (fluorescence); DNA; Combinatorial chemistry; Conjugate; Uridine; Fluorescence; RNA; Biochemistry; Click chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005867265,0.0005466518,0.0003655623,0.0002818163,0.00014129,0.000453561,0.0005953543,0.0005689028,0.0008620535],"category_scores_gemma":[0.0004301321,0.0004032314,0.0002793161,0.0001931126,0.0003737976,0.0005098021,0.0004667144,0.0009630431,0.0004459288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005333959,"about_ca_system_score_gemma":0.0003576869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000352723,"about_ca_topic_score_gemma":0.0005204816,"domain_scores_codex":[0.9995202,0.00007953031,0.00002909221,0.0001473545,0.0001563916,0.00006746406],"domain_scores_gemma":[0.9997736,0.00005052843,0.0000495766,0.00004175043,0.00003954653,0.00004497762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002027969,0.00001602992,0.00003224608,0.00002425687,0.000003124454,0.00001940655,0.00001030575,0.00009549571,0.9972292,0.0005366767,0.00002718084,0.001985779],"study_design_scores_gemma":[0.000002108289,0.0000334935,0.00008503325,9.370854e-7,0.000003324595,0.00006624449,0.000001662902,0.0006196566,0.9981629,0.00002761479,0.0009926233,0.000004353622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7266451,0.003883816,0.2617447,0.0003468021,0.0001941974,0.0001963911,0.0002469134,0.0007297432,0.006012404],"genre_scores_gemma":[0.9172778,0.001247298,0.07382819,0.00009931055,0.00002834232,0.0001044758,0.0002501107,0.00005912818,0.007105485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008620535,"threshold_uncertainty_score":0.00387013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02765259019329454,"score_gpt":0.27189281490049,"score_spread":0.2442402247071954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}