{"id":"W4210886204","doi":"10.1126/scisignal.abn2081","title":"Intrapore lipids hydrophobically gate pannexin-1 channels","year":2022,"lang":"en","type":"letter","venue":"Science Signaling","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Pannexin; Gating; Biophysics; Chemistry; Helix (gastropod); Terminal (telecommunication); Ion channel; Channel (broadcasting); Nanotechnology; Cell biology; Materials science; Biochemistry; Biology; Gap junction; Computer science; Receptor; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001023138,0.0004025072,0.0003573946,0.0002681215,0.0005971022,0.0001370938,0.001442533,0.0005798445,0.001039621],"category_scores_gemma":[0.0001646869,0.0003750081,0.0002310226,0.0005068732,0.000918833,0.00000728191,0.0007710895,0.00122779,0.00003906326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006917628,"about_ca_system_score_gemma":0.0006729596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000332954,"about_ca_topic_score_gemma":0.000002522443,"domain_scores_codex":[0.9965627,0.0001488605,0.0003930324,0.001342653,0.0005526713,0.001000039],"domain_scores_gemma":[0.9986549,0.00003492959,0.0002215949,0.0007911866,0.0001664901,0.0001308752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000460074,0.00002022679,0.0000180767,0.00003155415,0.00003757065,0.0001385691,0.00007164607,0.0003394858,0.7945219,0.00003162328,0.2034584,0.001284941],"study_design_scores_gemma":[0.0001747053,0.0006992317,0.000003499864,0.00002046128,0.00002155156,0.00007848959,0.00005461401,0.0001382671,0.06776495,0.0001915609,0.9303095,0.0005431253],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.6264232,0.002946373,0.001063959,0.3474735,0.01150369,0.001303699,0.00033235,0.0002020991,0.008751087],"genre_scores_gemma":[0.4674341,0.0001788508,0.0004293442,0.5129924,0.01257569,0.0001190013,0.001081733,0.0001085111,0.005080385],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7268511,"threshold_uncertainty_score":0.9998736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429039462228335,"score_gpt":0.2481368073786317,"score_spread":0.2338464127563483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}