{"id":"W4210886204","doi":"10.1126/scisignal.abn2081","title":"Intrapore lipids hydrophobically gate pannexin-1 channels","year":2022,"lang":"en","type":"letter","venue":"Science Signaling","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Pannexin; Gating; Biophysics; Chemistry; Helix (gastropod); Terminal (telecommunication); Ion channel; Channel (broadcasting); Nanotechnology; Cell biology; Materials science; Biochemistry; Biology; Gap junction; Computer science; Receptor; Intracellular","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001590277,0.0004823145,0.0004795522,0.0002830647,0.001602122,0.001838504,0.0008563387,0.01269,0.003779058],"category_scores_gemma":[0.006215417,0.0004185257,0.000508936,0.0002060602,0.00215808,0.001592316,0.0007411544,0.01303322,0.005067236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001891677,"about_ca_system_score_gemma":0.00108026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00116248,"about_ca_topic_score_gemma":0.00160615,"domain_scores_codex":[0.9990019,0.0002166306,0.00006373454,0.0001239097,0.0004606579,0.000133153],"domain_scores_gemma":[0.9976031,0.001296143,0.0001612168,0.0001468079,0.0004763561,0.0003163363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004364184,0.00009391117,0.0007323892,0.00008352879,0.00003307759,0.00261499,0.00009886245,0.0001813494,0.004665463,0.008432473,0.9538562,0.0287714],"study_design_scores_gemma":[0.0005001208,0.0002159047,0.001548712,0.00007528779,0.00003999572,0.002304817,0.0002562893,0.001508153,0.007326465,0.02510742,0.9610503,0.0000665912],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.004225919,0.005251165,0.0006539279,0.9047771,0.07727157,0.00002990833,0.0001037108,0.0001487687,0.007538061],"genre_scores_gemma":[0.05745886,0.007918332,0.0008148486,0.7805658,0.1245603,0.000102084,0.00009854607,0.00007293171,0.02840825],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01269,"threshold_uncertainty_score":0.0137251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429039462228335,"score_gpt":0.2481368073786317,"score_spread":0.2338464127563483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}