{"id":"W4210888864","doi":"10.1016/j.cell.2022.02.005","title":"Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2","year":2022,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":324,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; McMaster University","funders":"","keywords":"Immunization; Biology; Virology; Immunity; Nasal administration; Immunology; Mucosal immunity; Coronavirus disease 2019 (COVID-19); Vaccine efficacy; Attenuated vaccine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Vaccination; Antibody; Immune system; Medicine; Gene; Infectious disease (medical specialty); Genetics; Disease; Virulence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000712999,0.0001716871,0.0003326154,0.0002874575,0.0001865493,0.00002331366,0.0001379052,0.00009121245,0.00001576694],"category_scores_gemma":[0.0001503434,0.0001660529,0.00008620226,0.0003983057,0.0001019171,0.0001677405,0.0001137735,0.000345576,0.000001791817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002346058,"about_ca_system_score_gemma":0.001190496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005738866,"about_ca_topic_score_gemma":0.0002144446,"domain_scores_codex":[0.9981802,0.0002068616,0.0004471318,0.0003973574,0.0004957572,0.0002726808],"domain_scores_gemma":[0.9992172,0.0000516997,0.0002215224,0.0003180766,0.0001332834,0.00005821188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005287866,0.0003551621,0.003330054,0.000744405,0.00003428125,0.00007834677,0.0004496381,0.0001871973,0.990885,0.00003787369,0.001340771,0.002028441],"study_design_scores_gemma":[0.003467293,0.001824273,0.002062672,0.00003297094,0.00006647277,0.00003868897,0.0005893806,0.01011789,0.9587854,0.00004268131,0.02277483,0.0001975008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962221,0.0008329954,0.000806656,0.000224988,0.0001131487,0.001108226,0.00004493777,0.00004566757,0.0006012347],"genre_scores_gemma":[0.9909246,0.00001503088,0.0003183366,0.008362504,0.0001790375,0.0001235711,0.00001842136,0.00002812419,0.00003039936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03209969,"threshold_uncertainty_score":0.6771441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1542477520564269,"score_gpt":0.3351676284926312,"score_spread":0.1809198764362043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}