{"id":"W4210905631","doi":"10.1101/2022.02.07.22269422","title":"Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"Medical Research Council","keywords":"Medicine; Prediabetes; Tuberculosis; Diabetes mellitus; Transcriptome; Tb treatment; Comorbidity; Internal medicine; Immunology; Biomarker; Type 2 diabetes; Gene; Gene expression; Pathology; Biology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003595131,0.0002019316,0.0005480014,0.0003294126,0.0002798116,0.0007656588,0.000157993,0.0002349299,0.001478232],"category_scores_gemma":[0.001055245,0.0001363543,0.0004238231,0.0006214065,0.0002237675,0.0002381797,0.0004172372,0.0006416925,0.0002434693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003861561,"about_ca_system_score_gemma":0.0002587395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001553297,"about_ca_topic_score_gemma":0.001532452,"domain_scores_codex":[0.99953,0.0001412615,0.00003586768,0.0001368715,0.0000680973,0.00008790059],"domain_scores_gemma":[0.9994302,0.00009216493,0.000273386,0.00005348676,0.00007475191,0.00007599537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004100757,0.0002613518,0.8619291,0.0006372346,0.0005233972,0.0004795024,0.0004899019,0.001084575,0.08318519,0.0003272793,0.001335889,0.04564589],"study_design_scores_gemma":[0.00001672663,0.0002265314,0.9923315,0.00006323469,0.000122673,0.0003307396,0.0002561902,0.001227723,0.003599294,0.0003362714,0.001477306,0.00001177696],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920245,0.002836643,0.001153241,0.0002920832,0.00003845603,0.00002310719,0.002163886,0.00003277019,0.001435283],"genre_scores_gemma":[0.9972615,0.0005825403,0.0005575118,0.0001843711,0.00001983248,0.00002720828,0.001008902,0.000007808264,0.0003501817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553297,"threshold_uncertainty_score":0.004945159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05369194426907482,"score_gpt":0.3270771911009383,"score_spread":0.2733852468318635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}