{"id":"W4210914315","doi":"10.1073/pnas.2110329119","title":"Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Government of Canada; Glaucoma Foundation","keywords":"Neurovascular bundle; Pericyte; Glaucoma; Medicine; Retina; Retinal; Gene knockdown; Intraocular pressure; Blood flow; Homeostasis; Neuroscience; Ophthalmology; Cell biology; Pathology; Biology; Internal medicine; Endothelial stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009163881,0.00007695023,0.0001887594,0.0002434728,0.0001393891,0.0000062005,0.0002419273,0.00003351084,0.00001395379],"category_scores_gemma":[0.0003271245,0.00005323619,0.00007620544,0.0008699158,0.0004924662,0.0001461691,0.0001879062,0.0001977,1.715894e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000287382,"about_ca_system_score_gemma":0.00003352547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002009148,"about_ca_topic_score_gemma":8.415976e-8,"domain_scores_codex":[0.9984705,0.00001075702,0.0003077824,0.0002008544,0.0008941594,0.0001159258],"domain_scores_gemma":[0.9995605,0.00004089254,0.0002306082,0.000007649936,0.0001370458,0.00002328018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001664773,0.000144629,0.4503142,0.0003494453,0.00001920637,9.24263e-8,0.0009463753,0.00004389732,0.5437887,0.003529243,0.00003946964,0.0006582355],"study_design_scores_gemma":[0.000582371,0.0003764528,0.9258153,0.0001951567,0.0000288074,0.0001126435,0.001560014,0.004507303,0.06212445,0.004454941,0.0001657268,0.0000768371],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961991,0.0004653793,5.575335e-7,0.002154583,0.00002130311,0.0002236118,0.000003088582,0.000005724942,0.000926616],"genre_scores_gemma":[0.9994463,0.00006190975,0.0002888575,0.000133051,0.00001461243,0.00001170575,1.437844e-7,0.000004265703,0.00003920554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4816643,"threshold_uncertainty_score":0.2170909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01832324762018115,"score_gpt":0.2652436691617316,"score_spread":0.2469204215415505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}