{"id":"W4210914315","doi":"10.1073/pnas.2110329119","title":"Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma","year":2022,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Government of Canada; Glaucoma Foundation","keywords":"Neurovascular bundle; Pericyte; Glaucoma; Medicine; Retina; Retinal; Gene knockdown; Intraocular pressure; Blood flow; Homeostasis; Neuroscience; Ophthalmology; Cell biology; Pathology; Biology; Internal medicine; Endothelial stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002258802,0.0002350094,0.0002423645,0.0005474063,0.0002161058,0.0002413639,0.0001079953,0.0004049114,0.001884896],"category_scores_gemma":[0.0003062816,0.0001282607,0.0001849832,0.000169618,0.0004244992,0.0003307813,0.0002880676,0.0005184502,0.0001501659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001615464,"about_ca_system_score_gemma":0.0001905099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004531578,"about_ca_topic_score_gemma":0.000645119,"domain_scores_codex":[0.9998852,0.00002210932,0.0000147501,0.0000211788,0.00003161413,0.00002516213],"domain_scores_gemma":[0.9996921,0.00003771821,0.0001510079,0.00002174139,0.00002561805,0.00007181357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008481693,0.00009083691,0.01392798,0.0001718377,0.00006004583,0.001283412,0.0001344517,0.0001154814,0.9695488,0.0006171384,0.0003357444,0.0128661],"study_design_scores_gemma":[0.000105062,0.001820214,0.6371443,0.0001314552,0.0002900375,0.01222966,0.0007791575,0.003210425,0.3364531,0.001976001,0.005820272,0.00004033261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939823,0.003605799,0.001282256,0.0001687384,0.00003976783,0.00001117238,0.0001017024,0.00004553187,0.0007627105],"genre_scores_gemma":[0.9981009,0.0008762885,0.0004190979,0.00003254425,0.00001497911,0.00001155618,0.00004514875,0.000004398576,0.0004950596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884896,"threshold_uncertainty_score":0.006305635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01832324762018115,"score_gpt":0.2652436691617316,"score_spread":0.2469204215415505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}