{"id":"W4210924764","doi":"10.3389/fnagi.2021.784054","title":"Effects of Cognitive Reserve in Alzheimer’s Disease and Cognitively Unimpaired Individuals","year":2022,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Janssen Alzheimer Immunotherapy Research And Development; Korea Health Industry Development Institute; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; National Institute on Aging; Alzheimer's Association","keywords":"Cognitive reserve; Cognition; Disease; Neurodegeneration; Pathological; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; Cognitive decline; Psychology; Magnetic resonance imaging; Functional magnetic resonance imaging; Audiology; Effects of sleep deprivation on cognitive performance; Neuroscience; Internal medicine; Dementia; Medicine; Cognitive impairment","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002588546,0.000552579,0.0005804232,0.001099883,0.0004035406,0.000865913,0.0004876809,0.0005194836,0.0008886648],"category_scores_gemma":[0.006864512,0.0001882452,0.0007484758,0.0005772909,0.0006035285,0.0006275148,0.0009840165,0.0005326353,0.0001022686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003467785,"about_ca_system_score_gemma":0.0004017253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007287649,"about_ca_topic_score_gemma":0.007120959,"domain_scores_codex":[0.9991438,0.0003054404,0.00005324255,0.0003209525,0.00006949113,0.0001070648],"domain_scores_gemma":[0.9974368,0.0008999379,0.0007467185,0.000525194,0.0001182695,0.0002730505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002958315,0.0002270595,0.9725179,0.00009418309,0.0009072628,0.0004517784,0.0004861824,0.0008038344,0.002495318,0.0003214662,0.0002181506,0.01851843],"study_design_scores_gemma":[0.00001363837,0.0002513526,0.9970858,0.00001287135,0.0001827674,0.0001931379,0.0001140953,0.001049631,0.0003318589,0.000582094,0.0001743124,0.000008503466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983349,0.0007125059,0.0002765633,0.00006884192,0.000005716223,0.000006164535,0.0002393677,0.00001013497,0.0003457923],"genre_scores_gemma":[0.9995352,0.00005976909,0.0001596721,0.00002002695,0.000007969425,0.000004995173,0.000156366,0.000002476672,0.00005367102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007287649,"threshold_uncertainty_score":0.01449049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540366842443451,"score_gpt":0.3086077805519021,"score_spread":0.2832041121274675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}