{"id":"W4210926374","doi":"10.21203/rs.3.rs-1321818/v1","title":"Tolerability of Eribulin and Correlation Between Polymorphisms and Neuropathy in an Unselected Population of Female Patients with Metastatic Breast Cancer: Results of The Multicenter, Single Arm, Phase IV PAINTER Study","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"","keywords":"Medicine; Tolerability; Eribulin; Internal medicine; Neutropenia; Metastatic breast cancer; Gastroenterology; Breast cancer; Adverse effect; Febrile neutropenia; Oncology; Surgery; Cancer; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008847101,0.0003553092,0.0004328652,0.0002878809,0.0002237508,0.0004326439,0.0001614936,0.0003175382,0.001323423],"category_scores_gemma":[0.001088296,0.0001789382,0.0003595169,0.0003296973,0.0001551563,0.0002500206,0.0001694079,0.0002583023,0.0002746751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885551,"about_ca_system_score_gemma":0.0001131013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004399348,"about_ca_topic_score_gemma":0.0004570808,"domain_scores_codex":[0.9996533,0.0001510818,0.00002660062,0.00007816464,0.00005550727,0.00003535043],"domain_scores_gemma":[0.9991828,0.0001713877,0.0003507222,0.00006294822,0.0000824908,0.000149721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01006233,0.00081305,0.9786263,0.00003456358,0.0003333396,0.0002968236,0.000141657,0.000173402,0.003246715,0.00001332451,0.0002526454,0.00600587],"study_design_scores_gemma":[0.0005775731,0.007037743,0.9908171,0.000005151516,0.0001281073,0.000504013,0.000079087,0.0002232972,0.0003139903,0.00001844551,0.0002885038,0.000006920655],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995334,0.000132554,0.00003676155,0.00001050508,0.000001644504,0.00001367237,0.0001145922,0.000001681565,0.0001552968],"genre_scores_gemma":[0.9993551,0.00006399593,0.00004010198,0.00004742349,0.00001052965,0.00002174248,0.0002724262,0.000001560389,0.0001871651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323423,"threshold_uncertainty_score":0.004678845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06823118358957378,"score_gpt":0.4162965813409297,"score_spread":0.3480653977513559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}