{"id":"W4210942728","doi":"10.3390/ph15020202","title":"PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations","year":2022,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Bayerische Forschungsallianz; Deutscher Akademischer Austauschdienst","keywords":"Plasmodium falciparum; Drug resistance; Vacuole; ATP-binding cassette transporter; Biology; Transporter; Multiple drug resistance; Drug; P-glycoprotein; Membrane transport protein; Pharmacology; Gene; Molecular biology; Biochemistry; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006783325,0.0003504165,0.0005242259,0.0003870588,0.0005141636,0.00002544053,0.0001713884,0.00008633263,0.001469363],"category_scores_gemma":[0.00004920533,0.0003093719,0.0001437003,0.001325654,0.0001435496,0.0002372719,0.00002163189,0.001107384,0.00003008411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002405203,"about_ca_system_score_gemma":0.0004981619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001732044,"about_ca_topic_score_gemma":0.0002565325,"domain_scores_codex":[0.9971038,0.0002162669,0.0006494151,0.0006333867,0.0008026577,0.0005944827],"domain_scores_gemma":[0.9986675,0.000447368,0.0001539723,0.0002850128,0.000163245,0.0002828675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.032809,0.004803434,0.8766239,0.0008398436,0.001006489,0.00345639,0.005897577,0.01288963,0.04014189,0.01646184,0.0045481,0.0005219057],"study_design_scores_gemma":[0.01901881,0.0006374473,0.8792566,0.0006676071,0.001674672,0.000247025,0.004581194,0.00519225,0.03221305,0.004818209,0.04999751,0.001695648],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966806,0.0009934269,0.006608959,0.01380719,0.0004330624,0.001625378,0.0002261545,0.0003580833,0.009141744],"genre_scores_gemma":[0.9911689,0.00005194595,0.001314142,0.0006545943,0.0000645661,0.0004976731,0.0007745974,0.00007083709,0.005402808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04544941,"threshold_uncertainty_score":0.9999359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0544282573897075,"score_gpt":0.345585915004141,"score_spread":0.2911576576144335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}