{"id":"W4210948236","doi":"10.1042/bcj20210850","title":"Characterization of ADAT2/3 molecules in <i>Trypanosoma cruzi</i> and regulation of mucin gene expression by tRNA editing","year":2022,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of General Medical Sciences","keywords":"Transfer RNA; RNA editing; Druggability; Trypanosoma cruzi; Gene expression; Gene; Adenosine deaminase; Regulation of gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006274022,0.0000658299,0.0001011368,0.00004375563,0.00005622007,0.000007598823,0.00009894059,0.00005709361,0.00003275431],"category_scores_gemma":[0.00002780597,0.00006598284,0.00003606243,0.00008123553,0.00003991772,0.000006044189,0.00007793766,0.00009407363,5.537977e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001454053,"about_ca_system_score_gemma":0.00003811556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003824306,"about_ca_topic_score_gemma":2.054696e-7,"domain_scores_codex":[0.9992687,0.0000570448,0.0002932866,0.0001401762,0.000150759,0.00009004435],"domain_scores_gemma":[0.9995408,0.00000436556,0.0002486682,0.0001116627,0.00005518022,0.00003929266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006912207,0.00006465825,0.0007996134,0.00001076433,0.000005693556,3.881957e-7,0.0000280281,0.00002044037,0.9971021,0.000007298638,0.0007904594,0.001101461],"study_design_scores_gemma":[0.0004032738,0.00007636548,0.008124912,0.00001828774,0.000005216671,0.00002986819,0.00005304909,0.00008810848,0.9898048,0.00002758056,0.001305626,0.00006289075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996677,0.0009433846,0.002072336,0.00008914501,0.00005616803,0.00006041088,0.00006758986,0.000001507621,0.00003246609],"genre_scores_gemma":[0.9985967,0.0002688689,0.0006968209,0.00003960723,0.0001142613,0.00001049164,0.0002241182,0.000008794813,0.00004029477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007325299,"threshold_uncertainty_score":0.2690702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005979844133600126,"score_gpt":0.215974622976724,"score_spread":0.2099947788431238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}