{"id":"W4210953311","doi":"10.1007/978-3-030-74448-9_1","title":"Li-Fraumeni Syndrome","year":2021,"lang":"en","type":"book-chapter","venue":"","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Li–Fraumeni syndrome; Germline; Cancer; Phenotype; Medicine; Breast cancer; Sarcoma; Germline mutation; Oncology; Internal medicine; Genetics; Biology; Gene; Pathology; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001607548,0.0005465338,0.000310519,0.0007260134,0.0004413381,0.0008684484,0.0004160921,0.0008061696,0.03834886],"category_scores_gemma":[0.0003672825,0.0001481092,0.0002072122,0.0005412009,0.0005230124,0.0009096547,0.0007489392,0.001473382,0.01338445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000728962,"about_ca_system_score_gemma":0.0004978058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009776643,"about_ca_topic_score_gemma":0.003056602,"domain_scores_codex":[0.9999301,0.0000111746,0.00000268799,0.000009612093,0.00003773183,0.000008565542],"domain_scores_gemma":[0.9999398,0.00003445734,0.000003697623,0.000003867614,0.000009059984,0.000009095854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002329667,0.00002912595,0.000142953,0.0002382224,0.000009221348,0.001462202,0.0002248606,0.0003952957,0.00118192,0.1512029,0.5618556,0.2832344],"study_design_scores_gemma":[0.000002316463,0.000004614928,0.00009710137,0.00008699057,0.000002132223,0.001780205,0.00002236693,0.0000407476,0.0001223262,0.01200154,0.9858369,0.000002891321],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.00119002,0.08809955,0.005674186,0.007557536,0.005795965,0.00003437731,0.0002205723,0.000194248,0.8912334],"genre_scores_gemma":[0.006493879,0.04663316,0.003384915,0.003563064,0.001501813,0.00004281895,0.0001810353,0.00008515599,0.9381142],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.03834886,"threshold_uncertainty_score":0.1282897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174157753230079,"score_gpt":0.2328255212860469,"score_spread":0.2154097459630391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}