{"id":"W4210987592","doi":"10.1101/2022.02.09.479797","title":"Single-cell multi-region dissection of brain vasculature in Alzheimer’s Disease","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Biology; Pericyte; PDGFRB; Mural cell; CADASIL; Cell type; Human brain; Neuroscience; TREM2; Cell biology; Gene; Genetics; Receptor; Pathology; Cell; Endothelial stem cell; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652804,0.0001400743,0.000269416,0.0007155461,0.0001722273,0.000262673,0.0001288047,0.0002161218,0.0007522492],"category_scores_gemma":[0.0001405794,0.0001315411,0.0002276203,0.0004050284,0.0001454523,0.0001282278,0.0002218877,0.00017471,0.0001845882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001469051,"about_ca_system_score_gemma":0.00008994612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001281273,"about_ca_topic_score_gemma":0.002665817,"domain_scores_codex":[0.9999207,0.000007278104,0.000003699062,0.00003639948,0.00001636855,0.00001556378],"domain_scores_gemma":[0.9999305,0.0000139767,0.00001721224,0.000009527248,0.00001638458,0.00001253437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003187576,0.00001608413,0.04101023,0.00008460707,0.00009881348,0.0001250799,0.0001109554,0.0003860986,0.9487172,0.0001057245,0.0001834721,0.008842994],"study_design_scores_gemma":[0.00001595618,0.0002091306,0.9047202,0.00002538392,0.0002032443,0.0009853877,0.0003412145,0.005153175,0.08442561,0.0008700903,0.003031631,0.00001890917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931901,0.0009447157,0.003459687,0.00002782437,0.000007963524,0.00001068649,0.00185121,0.00004401784,0.0004637299],"genre_scores_gemma":[0.9938661,0.0003750764,0.003603544,0.00004338274,0.000007125612,0.00002508251,0.001480533,0.00001514135,0.0005839278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281273,"threshold_uncertainty_score":0.002547622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02265366927736826,"score_gpt":0.227291465814602,"score_spread":0.2046377965372337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}