{"id":"W4210993968","doi":"10.1038/s41467-022-28378-6","title":"In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Vanderbilt University; McGill University; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"CRISPR; Germinal center; Biology; Cell biology; PI3K/AKT/mTOR pathway; Autophagy; In vivo; mTORC1; Transcriptome; Signal transduction; Computational biology; B cell; Immunology; Gene; Genetics; Antibody; Gene expression; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002018075,0.0004361552,0.0003159859,0.0003308245,0.0002648493,0.0005117379,0.0002635304,0.0003968361,0.002056429],"category_scores_gemma":[0.0001372359,0.0001988863,0.0002727279,0.0001487007,0.0003559072,0.0001555899,0.0003126257,0.0005918575,0.0005312678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005058831,"about_ca_system_score_gemma":0.0002896042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008839222,"about_ca_topic_score_gemma":0.00187727,"domain_scores_codex":[0.9997621,0.00002814466,0.00001734417,0.00007230784,0.00006711546,0.00005297728],"domain_scores_gemma":[0.9998012,0.00004743932,0.00006831719,0.00001811935,0.00001453887,0.00005035371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006360168,0.00001171729,0.0003151277,0.00002541745,0.000007730298,0.00008618061,0.00001376286,0.0002149757,0.9976128,0.0001855394,0.00008782165,0.001375263],"study_design_scores_gemma":[0.00001343726,0.00009217591,0.00359537,0.000006729525,0.00002310264,0.0002508894,0.00003358409,0.001898839,0.98998,0.000115956,0.003983534,0.000006218478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579229,0.0008577061,0.02892473,0.0003249626,0.00006955842,0.00009672144,0.003748538,0.001224407,0.00683061],"genre_scores_gemma":[0.9860713,0.0003542198,0.007595683,0.000144175,0.000009120592,0.00004691394,0.001076906,0.0001474541,0.00455414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002056429,"threshold_uncertainty_score":0.006879389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526086982984424,"score_gpt":0.2703510178654882,"score_spread":0.2550901480356439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}