{"id":"W4210995635","doi":"10.3390/microorganisms10020398","title":"Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors","year":2022,"lang":"en","type":"article","venue":"Microorganisms","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Sterol; Squalene monooxygenase; Biology; Biochemistry; Sterol regulatory element-binding protein; Simvastatin; Pharmacology; Enzyme; Cholesterol; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009474959,0.0002230862,0.0002867021,0.0001580792,0.0001021048,0.0002152696,0.0001383596,0.0001807501,0.0009213217],"category_scores_gemma":[0.0001221594,0.0001388099,0.0002233333,0.0001101998,0.000136106,0.0001004546,0.000167745,0.000291013,0.0002240495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002300645,"about_ca_system_score_gemma":0.0001205174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008777283,"about_ca_topic_score_gemma":0.001209518,"domain_scores_codex":[0.9998569,0.00002640072,0.00001569578,0.00002588404,0.00003329509,0.00004178546],"domain_scores_gemma":[0.9999046,0.0000111674,0.00003598142,0.00001464691,0.00001646002,0.00001705808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004002238,0.000009623673,0.0002993857,0.00001205087,0.000002051526,0.0000412371,0.00001048079,0.000009623571,0.9992919,0.00001580761,0.000006552162,0.0002613039],"study_design_scores_gemma":[0.00002838389,0.0005565738,0.02643063,0.000005788059,0.00002884831,0.0008766789,0.0001471905,0.001269276,0.9688616,0.00006388801,0.001723082,0.000007992748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987219,0.00026864,0.0003705227,0.00004529297,0.000004209277,0.0000167354,0.0001366196,0.0000381312,0.00039794],"genre_scores_gemma":[0.9983228,0.0001468921,0.0004602315,0.00002936466,0.000002738754,0.00001450974,0.0002767868,0.00001056162,0.0007360667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009213217,"threshold_uncertainty_score":0.003082097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01870245608673322,"score_gpt":0.2764539334646456,"score_spread":0.2577514773779124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}