{"id":"W4211015323","doi":"10.1002/ange.202105562","title":"Enantioselective Synthesis of Spiro‐oxiranes: An Asymmetric Addition/Aldol/Spirocyclization Domino Cascade","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Stereocenter; Aldol reaction; Enantioselective synthesis; Domino; Chemistry; Nucleophile; Combinatorial chemistry; Cascade; Epoxide; Cascade reaction; Alkyne; Derivatization; Substrate (aquarium); Rhodium; Stereochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002715832,0.0002675995,0.000427546,0.0001910466,0.0001308893,0.00004692554,0.0002063922,0.0002720561,0.00646406],"category_scores_gemma":[0.002506771,0.0002899487,0.0001987843,0.001240348,0.0001050468,0.0002980699,0.00007031064,0.0001801157,0.00003860359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002090483,"about_ca_system_score_gemma":0.0002307511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006503513,"about_ca_topic_score_gemma":0.00003490526,"domain_scores_codex":[0.998012,0.00006133076,0.0005467062,0.0005806609,0.0005005015,0.0002987682],"domain_scores_gemma":[0.9976192,0.0007339687,0.0003225252,0.0005936002,0.0005743182,0.0001563623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005787347,0.0003543211,0.001581468,0.0003463407,0.0001557575,0.00002546364,0.0002500908,0.00006921106,0.9858174,0.0004386967,0.003173146,0.007730219],"study_design_scores_gemma":[0.0006170815,0.00001459728,0.001061287,0.0001068388,0.0001926697,0.00008476445,0.0003842462,0.00008160698,0.982495,0.0004276707,0.01424753,0.0002866763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7110255,0.003439614,0.03540926,0.0006730897,0.001005933,0.000527627,0.002063292,0.0008476706,0.245008],"genre_scores_gemma":[0.9840483,0.0003296679,0.006797416,0.000243209,0.0007869315,0.0001214079,0.002322257,0.0001035366,0.005247244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2730228,"threshold_uncertainty_score":0.9999552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02344140275314615,"score_gpt":0.2770036521128497,"score_spread":0.2535622493597036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}