{"id":"W4211017770","doi":"10.1016/j.atherosclerosis.2022.02.005","title":"The Cholesterol Uptake Capacity: The search for scalable HDL function tests continues","year":2022,"lang":"en","type":"letter","venue":"Atherosclerosis","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Mendelian randomization; Cholesterylester transfer protein; Medicine; Niacin; Internal medicine; Cholesterol; Dyslipidemia; Epidemiology; Lipoprotein; High-density lipoprotein; Reverse cholesterol transport; ABCA1; Endocrinology; Disease; Bioinformatics; Genetics; Biology; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002369166,0.000404583,0.0006599716,0.00006711877,0.001602951,0.0002436935,0.0004718075,0.0004790461,0.0001831035],"category_scores_gemma":[0.0001167304,0.0002261395,0.000903292,0.000290007,0.0002463642,0.00006837492,0.0001491396,0.002265633,0.00006169329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002751027,"about_ca_system_score_gemma":0.0002186568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00103254,"about_ca_topic_score_gemma":0.00007259181,"domain_scores_codex":[0.9963462,0.0003790414,0.0004692895,0.0006451177,0.001297734,0.0008626179],"domain_scores_gemma":[0.9971638,0.0004568731,0.0001917597,0.001837367,0.00025028,0.00009994399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001097262,0.00004802545,0.0005818288,0.0003307943,0.0007349564,0.000003056518,0.0002702419,0.000002857849,0.0004078049,0.0000385829,0.9403114,0.05716073],"study_design_scores_gemma":[0.001211309,0.000655786,0.01915893,0.0001489077,0.0005899598,0.00002768768,0.0001802573,0.00002607913,0.0002318756,0.00005528769,0.9774902,0.0002237547],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0735507,0.003730988,0.0004781744,0.9090011,0.003011882,0.007716986,0.0003738671,0.0002854365,0.001850938],"genre_scores_gemma":[0.03281414,0.002479826,0.0001908389,0.9028016,0.01576461,0.006096381,0.0005874902,0.0004757066,0.0387894],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05693698,"threshold_uncertainty_score":0.9996969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05233833178693929,"score_gpt":0.2651944001334172,"score_spread":0.2128560683464779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}