{"id":"W4211026324","doi":"10.1016/s2665-9913(21)00326-x","title":"Safety and preliminary efficacy of allogeneic bone marrow-derived multipotent mesenchymal stromal cells for systemic sclerosis: a single-centre, open-label, dose-escalation, proof-of-concept, phase 1/2 study","year":2022,"lang":"en","type":"article","venue":"The Lancet Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre; McGill University; McGill University Health Centre","funders":"Centre Hospitalier Universitaire de Rennes; Agence Nationale de la Recherche","keywords":"Medicine; Mesenchymal stem cell; Bone marrow; Stromal cell; Cell therapy; Scleroderma (fungus); Internal medicine; Pathology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001857429,0.001575108,0.001881816,0.000366276,0.0004173701,0.00150539,0.0007472877,0.001735806,0.003070374],"category_scores_gemma":[0.001162133,0.0005049969,0.001684915,0.0003412981,0.001239948,0.0009096097,0.0002747314,0.003517001,0.0007895525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006595483,"about_ca_system_score_gemma":0.001138588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004123281,"about_ca_topic_score_gemma":0.0008903264,"domain_scores_codex":[0.9993277,0.0003122492,0.00003364167,0.0001110461,0.00009477165,0.0001206776],"domain_scores_gemma":[0.9991624,0.0002077517,0.0001805555,0.00009945988,0.00006866061,0.0002812096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6479844,0.08819883,0.002355396,0.001853415,0.001635462,0.0002931897,0.0003675474,0.003766195,0.1408865,0.0004456405,0.003761036,0.1084523],"study_design_scores_gemma":[0.2677925,0.7110674,0.005681802,0.00006064265,0.0005652206,0.000251683,0.00008112871,0.001168155,0.01025733,0.0003701042,0.002660458,0.00004370376],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909855,0.003667949,0.001360942,0.0003594695,0.0001828774,0.001287071,0.0008559088,0.00012316,0.001177254],"genre_scores_gemma":[0.9901041,0.002064576,0.00182689,0.0008893646,0.0001918505,0.001491094,0.001479142,0.00004365842,0.001909316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003070374,"threshold_uncertainty_score":0.01027143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06829737147226164,"score_gpt":0.3034005507387278,"score_spread":0.2351031792664662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}