{"id":"W4211026324","doi":"10.1016/s2665-9913(21)00326-x","title":"Safety and preliminary efficacy of allogeneic bone marrow-derived multipotent mesenchymal stromal cells for systemic sclerosis: a single-centre, open-label, dose-escalation, proof-of-concept, phase 1/2 study","year":2022,"lang":"en","type":"article","venue":"The Lancet Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre; McGill University; McGill University Health Centre","funders":"Centre Hospitalier Universitaire de Rennes; Agence Nationale de la Recherche","keywords":"Medicine; Mesenchymal stem cell; Bone marrow; Stromal cell; Cell therapy; Scleroderma (fungus); Internal medicine; Pathology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000771291,0.0002557988,0.001386619,0.00009857016,0.0002832543,0.00001597446,0.0004126694,0.0001050962,0.0000804947],"category_scores_gemma":[0.0001775843,0.0001822465,0.0001008773,0.0002181908,0.0002464475,0.00005397166,0.0003805787,0.000200816,0.000001214631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008331561,"about_ca_system_score_gemma":0.0001594994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007243044,"about_ca_topic_score_gemma":0.000003513432,"domain_scores_codex":[0.9970494,0.0006482075,0.001104061,0.0004759876,0.0003205332,0.000401832],"domain_scores_gemma":[0.9977331,0.0006094833,0.0007562378,0.0006125121,0.0001670991,0.0001215561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.0817037,0.03728715,0.04859575,0.00259295,0.003721413,0.00008684307,0.02027767,0.002983594,0.7739173,0.0004197045,0.005429909,0.02298407],"study_design_scores_gemma":[0.5973198,0.05878842,0.1190553,0.01331127,0.007001713,0.0049862,0.05973179,0.02380049,0.1134291,0.0001075023,0.0004727372,0.001995729],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818985,0.01003348,0.0001295163,0.0008039165,0.0002872578,0.00660637,0.0001783271,0.00004310863,0.00001956015],"genre_scores_gemma":[0.9988306,0.0001640905,0.000293501,0.00006687719,0.00003667906,0.0004203372,0.00008362382,0.0000387215,0.00006552684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6604881,"threshold_uncertainty_score":0.7431797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06829737147226164,"score_gpt":0.3034005507387278,"score_spread":0.2351031792664662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}