{"id":"W4211035982","doi":"10.1016/j.lfs.2022.120380","title":"Hydrazonoyl chlorides possess promising antitumor properties","year":2022,"lang":"en","type":"article","venue":"Life Sciences","topic":"Synthesis of Organic Compounds","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"PTEN; PI3K/AKT/mTOR pathway; HeLa; Comet assay; Chemistry; Molecular biology; Protein kinase B; Ehrlich ascites carcinoma; Cancer research; Cytotoxicity; IC50; DNA damage; In vitro; Apoptosis; Biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001639097,0.0003528208,0.0003099313,0.0001864898,0.0001423915,0.0002064713,0.0003236931,0.0003443712,0.002683951],"category_scores_gemma":[0.0001585552,0.0001244135,0.0001459796,0.0001331661,0.000219469,0.0002169148,0.0002909415,0.0004192512,0.0009580307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001848242,"about_ca_system_score_gemma":0.0003007161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005574407,"about_ca_topic_score_gemma":0.0008128323,"domain_scores_codex":[0.9999135,0.00001716638,0.000005299983,0.00001172346,0.0000298609,0.00002252539],"domain_scores_gemma":[0.9999136,0.00001645894,0.00002105232,0.00001044481,0.00001919407,0.00001919343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002976089,0.00004232392,0.0002748045,0.0002042999,0.00001235911,0.0001388827,0.00003836856,0.000417077,0.9859489,0.001250074,0.0003344506,0.01104093],"study_design_scores_gemma":[0.00008450059,0.001043593,0.00102979,0.00001020663,0.00002221576,0.0003181118,0.00003121004,0.0002549996,0.9839104,0.0001715716,0.01310822,0.00001522316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9349722,0.01582082,0.01386327,0.0009488094,0.0002508762,0.0002441453,0.0008820969,0.0007056782,0.03231201],"genre_scores_gemma":[0.9839581,0.003870445,0.002051098,0.0002013907,0.00003985963,0.00004257875,0.0003483183,0.00003461806,0.009453508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002683951,"threshold_uncertainty_score":0.008978665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06484809559108776,"score_gpt":0.2807673261497622,"score_spread":0.2159192305586744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}