{"id":"W4211035982","doi":"10.1016/j.lfs.2022.120380","title":"Hydrazonoyl chlorides possess promising antitumor properties","year":2022,"lang":"en","type":"article","venue":"Life Sciences","topic":"Synthesis of Organic Compounds","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"PTEN; PI3K/AKT/mTOR pathway; HeLa; Comet assay; Chemistry; Molecular biology; Protein kinase B; Ehrlich ascites carcinoma; Cancer research; Cytotoxicity; IC50; DNA damage; In vitro; Apoptosis; Biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007187303,0.00010512,0.0002056166,0.0001430433,0.000848874,0.00007054769,0.0003598765,0.00001339491,0.000650259],"category_scores_gemma":[0.000478064,0.00007911643,0.00005467724,0.0005517376,0.0003696547,0.0002065768,0.0002353529,0.000133569,0.00003339528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006639799,"about_ca_system_score_gemma":0.0005622764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008364354,"about_ca_topic_score_gemma":0.000003394064,"domain_scores_codex":[0.9984632,0.00002899146,0.0001977294,0.0003337557,0.0006929416,0.0002834083],"domain_scores_gemma":[0.9995035,0.00005487265,0.0000734642,0.0002210634,0.000033465,0.0001136601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003288144,0.0007982998,0.2455839,0.0002274303,0.0001106578,0.000136172,0.004280189,0.0002639295,0.7273775,0.001752479,0.009326438,0.009814146],"study_design_scores_gemma":[0.002435088,0.00311466,0.1776892,0.0004474589,0.0002246842,0.002007641,0.02543197,0.007733173,0.6969439,0.001330913,0.08129591,0.001345398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834839,0.001047361,0.000006564837,0.008473406,0.0004858548,0.0002326089,0.000001622444,0.0001260515,0.006142659],"genre_scores_gemma":[0.9974906,0.00001139653,0.0005573194,0.0008503118,0.0002115872,0.00003047425,7.256155e-7,0.0000114168,0.0008361769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07196947,"threshold_uncertainty_score":0.711988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06484809559108776,"score_gpt":0.2807673261497622,"score_spread":0.2159192305586744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}