{"id":"W4211089092","doi":"10.1186/s40035-022-00284-3","title":"Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease","year":2022,"lang":"en","type":"article","venue":"Translational Neurodegeneration","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina; University of Saskatchewan","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Parkinson Society Canada; Canada Foundation for Innovation; University of Saskatchewan; Canadian Institutes of Health Research; Parkinson Canada; Saskatchewan Health Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Neurodegeneration; Adenosine; Synucleinopathies; Adenosine A1 receptor; Chemistry; Adenosine receptor; Pharmacology; Agonist; Parkinson's disease; Alpha-synuclein; Receptor; Neuroscience; Biochemistry; Biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008442767,0.0001833779,0.0001870838,0.00008484631,0.000135784,0.0001729107,0.0001282747,0.0002906955,0.0007348796],"category_scores_gemma":[0.00005234588,0.0001267712,0.0001591485,0.00005790135,0.0001128973,0.0001672844,0.0000787038,0.0002460643,0.0001664903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001754939,"about_ca_system_score_gemma":0.0000848125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005395722,"about_ca_topic_score_gemma":0.001207477,"domain_scores_codex":[0.999953,0.000009674934,0.000003329614,0.00001191272,0.00001084468,0.00001114274],"domain_scores_gemma":[0.9999737,0.000005248983,0.000008217508,0.000001925741,0.000003817002,0.000007134812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001196744,0.00002106086,0.0003463434,0.00004101205,0.000006941797,0.00006500746,0.000008007458,0.00008573802,0.998221,0.00005091367,0.0000384841,0.0009958399],"study_design_scores_gemma":[0.00005610356,0.001845025,0.05067167,0.0000431133,0.00009316417,0.00149423,0.0001366801,0.004522553,0.9363128,0.0004139725,0.004395068,0.00001552431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837166,0.0129477,0.001475021,0.0002046362,0.00002656545,0.0000179333,0.0001157537,0.00002742839,0.001468343],"genre_scores_gemma":[0.9934982,0.004054914,0.001078975,0.00009847987,0.00001265514,0.00001341789,0.0001024187,0.000002594794,0.001138373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007348796,"threshold_uncertainty_score":0.002458394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02924881093448001,"score_gpt":0.2718534815865444,"score_spread":0.2426046706520644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}