{"id":"W4211089092","doi":"10.1186/s40035-022-00284-3","title":"Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease","year":2022,"lang":"en","type":"article","venue":"Translational Neurodegeneration","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina; University of Saskatchewan","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Parkinson Society Canada; Canada Foundation for Innovation; University of Saskatchewan; Canadian Institutes of Health Research; Parkinson Canada; Saskatchewan Health Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Neurodegeneration; Adenosine; Synucleinopathies; Adenosine A1 receptor; Chemistry; Adenosine receptor; Pharmacology; Agonist; Parkinson's disease; Alpha-synuclein; Receptor; Neuroscience; Biochemistry; Biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000205403,0.0002367974,0.0002640922,0.0003494682,0.0004911628,0.0000533405,0.00008997205,0.00004490696,0.000166488],"category_scores_gemma":[0.00004871579,0.000262969,0.0001130083,0.0004254636,0.00002208333,0.00016818,0.00003561168,0.0001316833,0.0000103351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001191431,"about_ca_system_score_gemma":0.0001610405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001336234,"about_ca_topic_score_gemma":0.00002041651,"domain_scores_codex":[0.9982406,0.00006278163,0.0003979848,0.0006729937,0.000328787,0.0002968377],"domain_scores_gemma":[0.9991236,0.00007798299,0.00007900091,0.0002579249,0.00008468238,0.0003768408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00522961,0.002693974,0.3364072,0.0002235541,0.0001706502,0.00006484977,0.001265076,0.01431075,0.5799625,0.0219781,0.003845255,0.03384853],"study_design_scores_gemma":[0.004613094,0.0006359064,0.8915235,0.00003540106,0.0002328646,0.00002508388,0.0000339948,0.008710752,0.007991473,0.001330077,0.08447154,0.0003963495],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758834,0.0005652762,0.001874951,0.01872228,0.0001782796,0.001652435,0.0009923165,0.00007540308,0.00005567897],"genre_scores_gemma":[0.9917257,0.00006338768,0.004038646,0.001501488,0.0001702757,0.001211307,0.001057268,0.00006341472,0.0001685569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.571971,"threshold_uncertainty_score":0.9999822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02924881093448001,"score_gpt":0.2718534815865444,"score_spread":0.2426046706520644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}