{"id":"W4211095709","doi":"10.1007/s11010-022-04386-4","title":"H2S protects from oxidative stress-driven ACE2 expression and cardiac aging","year":2022,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Laurentian University","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Oxidative stress; Angiotensin-converting enzyme 2; Senescence; Internal medicine; Endocrinology; Oxidative phosphorylation; Knockout mouse; Endogeny; Clinical chemistry; Chemistry; Biology; Medicine; Biochemistry; Receptor; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002121811,0.0003859653,0.0004523042,0.0002498723,0.0002096667,0.0003122474,0.0002046743,0.0002686782,0.001520762],"category_scores_gemma":[0.0001341301,0.0001668657,0.000338915,0.0001314495,0.0004035065,0.0002449198,0.0002458603,0.0004704577,0.0002219023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002822907,"about_ca_system_score_gemma":0.0002986046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211264,"about_ca_topic_score_gemma":0.00167445,"domain_scores_codex":[0.9998828,0.00002410039,0.000009456803,0.00002284095,0.00001923891,0.00004161652],"domain_scores_gemma":[0.999798,0.00001101206,0.00004928727,0.00002959757,0.00002805009,0.00008406497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003119574,0.0001488771,0.000676484,0.00003520541,0.0000323137,0.00006994812,0.00002191874,0.00004793629,0.9933768,0.0001472855,0.0001381207,0.002185564],"study_design_scores_gemma":[0.0001222423,0.001308938,0.03013749,0.00001077514,0.00006698614,0.0001826985,0.0001354813,0.0009120625,0.9647166,0.0002429793,0.002148873,0.00001502768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959201,0.001493614,0.001295444,0.0001746647,0.00009144201,0.0000142011,0.0002190782,0.0001029221,0.0006885801],"genre_scores_gemma":[0.9955114,0.0005431283,0.0005578582,0.00006667592,0.00004081504,0.0000186212,0.000317775,0.00002141513,0.002922311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001520762,"threshold_uncertainty_score":0.005087435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005282432485288054,"score_gpt":0.2106260859203313,"score_spread":0.2053436534350433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}