{"id":"W4211111290","doi":"10.21203/rs.3.rs-1335575/v1","title":"Synovial Membrane-derived Mesenchymal Progenitor Cells From Osteoarthritic Joints in Dogs Possess Lower Chondrogenic-, and Higher Osteogenic Capacity Compared to Normal Joints","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Arthritis Society; Dutch Arthritis Society","keywords":"Chondrogenesis; Mesenchymal stem cell; Progenitor cell; Osteoarthritis; Synovial membrane; Cell biology; Chemistry; Materials science; Biomedical engineering; Medicine; Biology; Arthritis; Pathology; Stem cell; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000279122,0.000224515,0.000330307,0.000847246,0.0002473262,0.0004830969,0.0001430949,0.0002880179,0.002184377],"category_scores_gemma":[0.0002495754,0.0001978698,0.0002749096,0.0003290639,0.000331809,0.0002547569,0.0003256171,0.0004397239,0.0005585779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002159782,"about_ca_system_score_gemma":0.0002642406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008552321,"about_ca_topic_score_gemma":0.001125714,"domain_scores_codex":[0.9996755,0.0000283365,0.0000479094,0.00006220103,0.0001247451,0.0000612479],"domain_scores_gemma":[0.9997292,0.00003484872,0.00009554139,0.00002267373,0.00004950821,0.00006816487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004898995,0.00007531105,0.009503473,0.0001820994,0.00001833432,0.0003772261,0.0001604815,0.00008203411,0.9852098,0.0001192058,0.00007519235,0.003707099],"study_design_scores_gemma":[0.00008104178,0.003977592,0.238157,0.00007828903,0.0001753615,0.009692848,0.001944003,0.002174508,0.7319499,0.0002569431,0.01147875,0.0000337595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970551,0.0009659466,0.001070827,0.00002723437,0.00001183523,0.00002611372,0.0002782402,0.00001906253,0.0005457289],"genre_scores_gemma":[0.9963373,0.0004067159,0.001132534,0.00002793991,0.0000118222,0.00003216285,0.0007591963,0.000007461803,0.001284898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002184377,"threshold_uncertainty_score":0.007307529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05669594930248926,"score_gpt":0.3361662808797563,"score_spread":0.279470331577267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}