{"id":"W4211113798","doi":"10.1007/978-0-387-77236-3_11","title":"Li–Fraumeni Syndrome","year":2009,"lang":"en","type":"book-chapter","venue":"","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"","keywords":"Li–Fraumeni syndrome; Proband; Rhabdomyosarcoma; Medicine; Cancer; Sarcoma; Lung cancer; Internal medicine; Oncology; Pathology; Biology; Germline mutation; Gene; Mutation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00006704459,0.0003985088,0.0006477266,0.0002379564,0.00003191053,0.00001454749,0.000112073,0.000734869,0.008755782],"category_scores_gemma":[0.00001448631,0.0003649032,0.0003471053,0.00003166304,0.00005948213,0.00002386634,0.00004770901,0.0007558838,0.003237515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002688017,"about_ca_system_score_gemma":0.0002394274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001559677,"about_ca_topic_score_gemma":0.0000112395,"domain_scores_codex":[0.9984362,0.000004445694,0.0003458601,0.0004817936,0.0004539585,0.0002777597],"domain_scores_gemma":[0.9987936,0.00001440579,0.000113784,0.0007456663,0.00008748394,0.0002450797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004132755,0.0002449678,0.000006952082,0.0005747871,0.002218388,0.02830862,0.0001391779,0.00001423458,0.003720986,0.3353871,0.3208992,0.3080723],"study_design_scores_gemma":[0.0009790331,0.0007461883,0.00004892596,0.0007259275,0.0004487988,0.003282907,0.000001865696,0.00001090162,0.0003265383,0.004623956,0.9883854,0.0004195346],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.00005597646,0.002452522,0.0001901979,0.0008395264,0.0003162372,0.000574997,0.00001613706,0.00029881,0.9952556],"genre_scores_gemma":[0.003038969,0.0004825915,0.0007374022,0.002149654,0.0002227443,0.00000632292,0.0001368225,0.0001307687,0.9930947],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.6674863,"threshold_uncertainty_score":0.9998803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498583471404441,"score_gpt":0.2315161002724146,"score_spread":0.2165302655583702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}