{"id":"W4211115069","doi":"10.1038/s43586-021-00028-z","title":"Bioorthogonal chemistry","year":2021,"lang":"nl","type":"article","venue":"Nature Reviews Methods Primers","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":559,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institute of General Medical Sciences","keywords":"Bioorthogonal chemistry; Chemistry; Chemical biology; Click chemistry; Combinatorial chemistry; Bioconjugation; Tetrazine; Nanotechnology; Organic chemistry; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007608272,0.001107556,0.0004603559,0.0008225113,0.000534404,0.001061155,0.0008863664,0.001331238,0.01162895],"category_scores_gemma":[0.0004105197,0.0005792897,0.0003749759,0.000555967,0.0005738255,0.00119226,0.001486235,0.002154156,0.01173821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006567677,"about_ca_system_score_gemma":0.0006365876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002785027,"about_ca_topic_score_gemma":0.0006286968,"domain_scores_codex":[0.9992872,0.0000977907,0.00003666179,0.0001642532,0.000284845,0.0001293218],"domain_scores_gemma":[0.9998603,0.0000221664,0.00002541194,0.00003765271,0.00003285455,0.00002160461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000135109,0.0002195773,0.0002208028,0.001003622,0.00007526146,0.0002378613,0.0001853365,0.0002274835,0.6550327,0.08993293,0.04133355,0.2113958],"study_design_scores_gemma":[0.0000203782,0.0001654602,0.0002178741,0.0000458287,0.00002094598,0.0003959441,0.00003176705,0.0004843646,0.610153,0.005131375,0.3833083,0.00002482122],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.07084256,0.06349161,0.388467,0.004707004,0.007691151,0.001225384,0.002273137,0.004282359,0.4570199],"genre_scores_gemma":[0.3833649,0.0507481,0.1231745,0.00385696,0.001493355,0.001290095,0.003999785,0.000540077,0.4315321],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.01162895,"threshold_uncertainty_score":0.03890276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04084773897256575,"score_gpt":0.4271638263924606,"score_spread":0.3863160874198948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}