{"id":"W4211134828","doi":"10.1002/alz.12581","title":"Trans‐seeding of Alzheimer‐related tau protein by a yeast prion","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Universitätsspital Basel; Mach-Gaensslen Foundation of Canada; National Science Foundation; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Fibril; Neurodegeneration; Prion protein; Protein aggregation; Tau protein; Yeast; Amyloid (mycology); Cell biology; In vivo; In vitro; Genetically modified mouse; Biology; Chemistry; Biochemistry; Transgene; Alzheimer's disease; Disease; Genetics; Gene; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770418,0.000247765,0.0001339613,0.00009478167,0.0001098331,0.0002169574,0.0001025739,0.0001402133,0.0002873627],"category_scores_gemma":[0.0001198105,0.00006198698,0.000160025,0.00008570821,0.0001269864,0.000137148,0.000245899,0.0002000619,0.0001428722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007985389,"about_ca_system_score_gemma":0.00009151232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003705409,"about_ca_topic_score_gemma":0.0005289546,"domain_scores_codex":[0.9999161,0.00002721024,0.000006522179,0.00001949595,0.00001850315,0.00001218429],"domain_scores_gemma":[0.9999008,0.0000236607,0.00002710633,0.0000191479,0.00001223288,0.00001697638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005714299,0.00001695751,0.0004572616,0.00002299644,0.000004518759,0.0001336047,0.00002809174,0.00005116084,0.9983772,0.00008519836,0.00001186295,0.0007540239],"study_design_scores_gemma":[0.000006306453,0.0004853422,0.004567913,0.000007667062,0.00001553621,0.0006356054,0.00008804261,0.000929359,0.992372,0.00007973247,0.0008089116,0.000003672807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996789,0.0004761161,0.002184204,0.00001418774,0.000006707863,0.00000827117,0.00003626825,0.00001461291,0.0004706443],"genre_scores_gemma":[0.9966744,0.0003309415,0.002369589,0.00001282886,0.000002436359,0.000006335461,0.00007112511,0.000005797114,0.0005264636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003705409,"threshold_uncertainty_score":0.0009613037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01270807146733712,"score_gpt":0.2425458464265411,"score_spread":0.229837774959204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}