{"id":"W4211134996","doi":"10.1371/journal.pgen.1010028","title":"A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5’ splice site identity","year":2022,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Molecular and Cellular Biosciences; National Institute of General Medical Sciences; University of British Columbia; Oklahoma Medical Research Foundation; Genome Canada; National Institutes of Health; National Science Foundation","keywords":"Spliceosome; RNA splicing; Biology; Intron; Splice site mutation; splice; Genetics; Alternative splicing; Splicing factor; Gene; Polypyrimidine tract; Computational biology; Messenger RNA; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141693,0.000488826,0.0002422869,0.000617336,0.0003273514,0.0001942008,0.0004291006,0.0003411218,0.001591003],"category_scores_gemma":[0.0001643509,0.0002201911,0.0003693668,0.0002659218,0.0002464762,0.0001010313,0.0002396263,0.0003447539,0.0004004452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003804867,"about_ca_system_score_gemma":0.000405707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003526685,"about_ca_topic_score_gemma":0.009353181,"domain_scores_codex":[0.9998007,0.00001162136,0.00002352159,0.00004810257,0.00008216154,0.00003398028],"domain_scores_gemma":[0.9997486,0.00006385284,0.00007297809,0.0000254037,0.00002546415,0.000063659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006246658,0.00002329871,0.0007533521,0.00003732957,0.00001073501,0.0002336305,0.00001044433,0.00009326721,0.9975586,0.00007327151,0.000050498,0.001093052],"study_design_scores_gemma":[0.00001643632,0.0001685738,0.02098585,0.00001152527,0.00004825696,0.0007521266,0.00004520391,0.001399217,0.9741215,0.00004000974,0.002395953,0.00001520661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926197,0.0005214403,0.002802804,0.00007453452,0.00001718445,0.00007708884,0.002273427,0.0001857847,0.001428176],"genre_scores_gemma":[0.9853542,0.0003943567,0.007975143,0.00008162719,0.000003364077,0.00008949924,0.002151254,0.00007684688,0.003873738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003526685,"threshold_uncertainty_score":0.007012308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740070946733541,"score_gpt":0.2825520078237611,"score_spread":0.2651512983564256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}