{"id":"W4211134996","doi":"10.1371/journal.pgen.1010028","title":"A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5’ splice site identity","year":2022,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Molecular and Cellular Biosciences; National Institute of General Medical Sciences; University of British Columbia; Oklahoma Medical Research Foundation; Genome Canada; National Institutes of Health; National Science Foundation","keywords":"Spliceosome; RNA splicing; Biology; Intron; Splice site mutation; splice; Genetics; Alternative splicing; Splicing factor; Gene; Polypyrimidine tract; Computational biology; Messenger RNA; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004256754,0.0001341606,0.0001747526,0.0001322518,0.0001205559,0.00003308855,0.0002418683,0.00007100707,0.00001229493],"category_scores_gemma":[0.0001111146,0.0001568569,0.00004396452,0.0001833824,0.00004327312,0.000005502914,0.0004077491,0.0001688623,0.00000171532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004300283,"about_ca_system_score_gemma":0.00007139747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008020431,"about_ca_topic_score_gemma":0.001943928,"domain_scores_codex":[0.9985533,0.0001252778,0.0002656998,0.0004010338,0.0002177485,0.0004369261],"domain_scores_gemma":[0.9995017,0.00003216587,0.00005907282,0.000270777,0.00004128027,0.00009499568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001191578,0.00008490585,0.1756189,0.00004110891,0.00002082307,0.00002210144,0.0001709822,0.001467783,0.8212566,0.00003958992,0.0001340173,0.001023967],"study_design_scores_gemma":[0.0103958,0.004338331,0.5794705,0.0002147151,0.0001228628,0.0001468513,0.004062283,0.1090278,0.2727639,0.003487396,0.01380836,0.002161176],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957573,0.002873231,0.0004908849,0.0001228916,0.00001949905,0.0005655909,0.00008644244,0.000006060679,0.000078095],"genre_scores_gemma":[0.9963452,0.0004490488,0.002349249,0.0002300237,0.00009200259,0.0001898887,0.00007219431,0.00003144305,0.0002410007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5484927,"threshold_uncertainty_score":0.639644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740070946733541,"score_gpt":0.2825520078237611,"score_spread":0.2651512983564256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}