{"id":"W4211138113","doi":"10.1093/femsyr/foac004","title":"Proteasome activity modulates amyloid toxicity","year":2022,"lang":"en","type":"article","venue":"FEMS Yeast Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Institute of General Medical Sciences; Fiducie de Recherche sur la Foret des Cantons-de-l'Est; Kidney Research UK","keywords":"Proteasome; Biology; Cell biology; Chaperone (clinical); Amyloid (mycology); Phenotype; Lactacystin; Amyloid precursor protein; Yeast; Gene; Biochemistry; Alzheimer's disease; Proteasome inhibitor; Disease; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001202177,0.0003422393,0.0003093793,0.0001606748,0.0001640955,0.0005465765,0.0001238525,0.000334675,0.001146951],"category_scores_gemma":[0.0001316338,0.0001197899,0.0001880906,0.0001612457,0.0002192883,0.0001922755,0.0001918512,0.0004022568,0.0003547575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002351843,"about_ca_system_score_gemma":0.0001401043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002061697,"about_ca_topic_score_gemma":0.0002955623,"domain_scores_codex":[0.999886,0.00001885698,0.00001061226,0.00002410111,0.00001919823,0.00004114358],"domain_scores_gemma":[0.999916,0.00001007974,0.00002589737,0.00000666326,0.00001189321,0.00002947323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005270514,0.00007113509,0.0004886365,0.00006385441,0.00001524567,0.00014048,0.0000142316,0.00004946564,0.9960046,0.0001297957,0.0001006381,0.002394874],"study_design_scores_gemma":[0.00009581987,0.001418806,0.03937385,0.00002237367,0.00007657574,0.000969092,0.00008687022,0.0009392874,0.9502916,0.0003867434,0.006323421,0.00001553536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839062,0.01247254,0.0008043936,0.0001679968,0.00009714634,0.00001918054,0.0002817257,0.00006146238,0.002189478],"genre_scores_gemma":[0.9947038,0.00366899,0.0001992395,0.00004972444,0.0000296782,0.0000127141,0.0002111748,0.000009549003,0.00111507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146951,"threshold_uncertainty_score":0.00383693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0319400083615294,"score_gpt":0.3256826615956682,"score_spread":0.2937426532341388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}