{"id":"W4211138113","doi":"10.1093/femsyr/foac004","title":"Proteasome activity modulates amyloid toxicity","year":2022,"lang":"en","type":"article","venue":"FEMS Yeast Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Institute of General Medical Sciences; Fiducie de Recherche sur la Foret des Cantons-de-l'Est; Kidney Research UK","keywords":"Proteasome; Biology; Cell biology; Chaperone (clinical); Amyloid (mycology); Phenotype; Lactacystin; Amyloid precursor protein; Yeast; Gene; Biochemistry; Alzheimer's disease; Proteasome inhibitor; Disease; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005785533,0.0001151603,0.0001093011,0.00008122159,0.0004910128,0.00004668214,0.0003622115,0.00005714653,0.0004155266],"category_scores_gemma":[0.0001576148,0.0001128518,0.00008974467,0.0002265381,0.0001405557,0.000004466936,0.0008091591,0.0003739575,0.00004182792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005395851,"about_ca_system_score_gemma":0.0001772297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001495083,"about_ca_topic_score_gemma":0.00001528307,"domain_scores_codex":[0.9979933,0.0003572742,0.0001039938,0.0004432123,0.0006188775,0.0004833254],"domain_scores_gemma":[0.9991727,0.00001603169,0.0000322362,0.0004825625,0.0001030487,0.0001934526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003694984,0.0003967166,0.006061262,0.00003054499,0.00003362403,0.00002875678,0.00004730864,0.0004230811,0.9807079,0.0002086717,0.007325077,0.004367574],"study_design_scores_gemma":[0.001400968,0.001013524,0.02718946,0.00001336479,0.00001009375,0.00005568251,0.0004737813,0.002013057,0.8480235,0.0008042203,0.11849,0.0005124111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934572,0.0003135261,0.00006256663,0.0003144586,0.00008950114,0.0004094783,0.0001303567,0.00001786949,0.005205054],"genre_scores_gemma":[0.9952458,0.00003284311,0.0000400749,0.00004688717,0.0002023524,0.0003881918,0.00007920192,0.00002326406,0.003941348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1326844,"threshold_uncertainty_score":0.4601965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0319400083615294,"score_gpt":0.3256826615956682,"score_spread":0.2937426532341388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}