{"id":"W4211148931","doi":"10.1242/jcs.259297","title":"Hedgehog pathway modulation by glypican 3-conjugated heparan sulfate","year":2022,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; Kidney Foundation of Canada","keywords":"Heparan sulfate; Glypican 3; Biology; Cell biology; Glycosaminoglycan; Signal transduction; Chondroitin sulfate; Hedgehog; Ectodomain; Hedgehog signaling pathway; Heparanase; Biochemistry; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006361882,0.0001900036,0.0000977565,0.000095815,0.000117982,0.0001744422,0.00008929396,0.0001311839,0.0005652442],"category_scores_gemma":[0.00004435296,0.00006983953,0.0001198336,0.00007762977,0.0002324345,0.00008547584,0.0001272326,0.000267249,0.0001351766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002805122,"about_ca_system_score_gemma":0.0001846203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009074014,"about_ca_topic_score_gemma":0.001443225,"domain_scores_codex":[0.9999441,0.00001353349,0.000003367153,0.00000718002,0.00001488987,0.00001691454],"domain_scores_gemma":[0.9999756,0.00000565765,0.000004576149,0.000002450289,0.000002207603,0.00000954311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005053504,0.000005932347,0.00004412173,0.000006861433,0.000001275182,0.00002532046,0.000004626033,0.00001720103,0.9995603,0.0000471469,0.000009225489,0.0002273118],"study_design_scores_gemma":[0.00000812388,0.00006784303,0.001774836,0.000001475124,0.000003336642,0.00007050981,0.00001547994,0.0003332832,0.9972292,0.00002941978,0.0004650943,0.000001551545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983407,0.0003003406,0.000429209,0.00003563687,0.000009480133,0.000006961432,0.00008049234,0.00001333765,0.0007837088],"genre_scores_gemma":[0.9982731,0.000264817,0.0005404456,0.00003158483,0.000002877894,0.000006902813,0.0001211711,0.000004644754,0.0007543635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009074014,"threshold_uncertainty_score":0.00203526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008448523705151955,"score_gpt":0.2325912182416423,"score_spread":0.2241426945364903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}