{"id":"W4211153257","doi":"10.1016/j.drup.2003.10.002","title":"DNA methylation and cancer therapy","year":2003,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; CpG site; Methylation; Biology; DNA methyltransferase; Epigenomics; RNA-Directed DNA Methylation; Methyltransferase; DNA; Illumina Methylation Assay; Epigenetics of physical exercise; Epigenetics; Cancer epigenetics; Cancer research; Genetics; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001038196,0.001103632,0.001944623,0.001729424,0.0004819616,0.001310115,0.001376622,0.002009834,0.005248278],"category_scores_gemma":[0.0009529209,0.0004011637,0.0004619452,0.001628805,0.001089134,0.001536273,0.0009304322,0.003948406,0.002936854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001165714,"about_ca_system_score_gemma":0.001032708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001508556,"about_ca_topic_score_gemma":0.004787827,"domain_scores_codex":[0.9997031,0.00007178348,0.00002505249,0.00004840521,0.0001211554,0.00003041075],"domain_scores_gemma":[0.999725,0.0001203563,0.00002747547,0.00001565682,0.00007738017,0.00003403216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001383446,0.00009636911,0.000148921,0.003184651,0.00006521032,0.0003376419,0.00005676041,0.0005686976,0.002966641,0.006621697,0.1155562,0.8702589],"study_design_scores_gemma":[0.0000276623,0.00004516877,0.0002238226,0.0004411417,0.00003628125,0.0007367565,0.00002619027,0.0001319929,0.0004899173,0.002485903,0.995346,0.000009124764],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009344531,0.9947555,0.0004207538,0.001327101,0.001386964,0.000007733413,0.00001267029,0.00001700119,0.001978763],"genre_scores_gemma":[0.001304165,0.9900807,0.0006479414,0.0014121,0.001837912,0.0000174643,0.00003845644,0.000004987549,0.004656401],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005248278,"threshold_uncertainty_score":0.01755726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666833700517556,"score_gpt":0.3297473750495071,"score_spread":0.3030790380443315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}