{"id":"W4211153257","doi":"10.1016/j.drup.2003.10.002","title":"DNA methylation and cancer therapy","year":2003,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"DNA methylation; CpG site; Methylation; Biology; DNA methyltransferase; Epigenomics; RNA-Directed DNA Methylation; Methyltransferase; DNA; Illumina Methylation Assay; Epigenetics of physical exercise; Epigenetics; Cancer epigenetics; Cancer research; Genetics; Molecular biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002687047,0.0003283014,0.0005455446,0.00006663772,0.00009616883,0.00005477769,0.000147377,0.0002664079,0.0000327934],"category_scores_gemma":[0.00003207344,0.000274974,0.0001606156,0.0001356989,0.00006478553,0.000003663713,0.00003947702,0.000117572,0.000006266093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002305361,"about_ca_system_score_gemma":0.0001258145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005853065,"about_ca_topic_score_gemma":0.00006977186,"domain_scores_codex":[0.9985947,0.0001924882,0.0003444314,0.0005250974,0.0001281825,0.000215124],"domain_scores_gemma":[0.9991833,0.00003250864,0.000264479,0.0003776584,0.00007293281,0.00006914716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001295322,0.00002022592,0.00002110459,0.001269133,0.0001383266,9.69174e-7,0.00002005935,0.000001018183,0.001158804,0.0001337222,0.002447784,0.9947759],"study_design_scores_gemma":[0.0001398986,0.00001158717,0.000008968434,0.0005099867,0.00008775597,4.694348e-7,0.000004300351,3.33866e-7,0.005102828,0.0002064266,0.9936104,0.000317063],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005031818,0.9977698,0.00007256731,0.00003542143,0.000178644,0.0003776672,0.00006897416,0.00001062159,0.0009831074],"genre_scores_gemma":[0.0000610999,0.9926135,0.0004252791,0.00004664714,0.0001910926,0.0001252016,0.0005296068,0.00005979955,0.005947753],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9944589,"threshold_uncertainty_score":0.9999703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02666833700517556,"score_gpt":0.3297473750495071,"score_spread":0.3030790380443315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}