{"id":"W4211162220","doi":"10.1007/s11307-021-01697-8","title":"A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking","year":2022,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"St Joseph's Health Care; Ontario Institute for Cancer Research; Lawson Health Research Institute; Western University","funders":"National Institute of Biomedical Imaging and Bioengineering; Ontario Institute for Cancer Research; Foundation for the National Institutes of Health","keywords":"Reporter gene; Sodium-iodide symporter; Magnetic resonance imaging; Positron emission tomography; Cancer research; Nuclear medicine; Chemistry; Medicine; Gene; Symporter; Transporter; Gene expression; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005998577,0.0005393172,0.0005573579,0.0003885148,0.0003216858,0.0006366234,0.0007139225,0.0008081475,0.001714107],"category_scores_gemma":[0.0002648018,0.0003634942,0.0003448458,0.0004199799,0.0003434799,0.0003873812,0.000458369,0.001163741,0.001409749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005099069,"about_ca_system_score_gemma":0.0006591766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006417276,"about_ca_topic_score_gemma":0.0009420296,"domain_scores_codex":[0.999729,0.00005662782,0.00001643254,0.00008679468,0.00006718266,0.00004394582],"domain_scores_gemma":[0.9998595,0.00002773444,0.00002355471,0.00002103881,0.00002695459,0.00004117974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023704,0.00001793703,0.00004732304,0.00003236307,0.000005067435,0.00003107536,0.00001349737,0.0000678188,0.9972029,0.0003369742,0.0002020949,0.001940539],"study_design_scores_gemma":[0.00002573892,0.0001511197,0.0003086354,0.000005347725,0.00003288647,0.0004949145,0.000007592615,0.001264348,0.9859533,0.00006770362,0.01167885,0.000009451975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6115825,0.005196162,0.3667227,0.001224583,0.000463786,0.0006667959,0.003356072,0.002214173,0.008573199],"genre_scores_gemma":[0.728411,0.002793023,0.2365644,0.0004607343,0.000110526,0.0006364543,0.007430836,0.0004157191,0.02317736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001714107,"threshold_uncertainty_score":0.005734265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105443847527218,"score_gpt":0.2586927777730287,"score_spread":0.2481483930203069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}