{"id":"W4211162220","doi":"10.1007/s11307-021-01697-8","title":"A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking","year":2022,"lang":"en","type":"article","venue":"Molecular Imaging and Biology","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"St Joseph's Health Care; Ontario Institute for Cancer Research; Lawson Health Research Institute; Western University","funders":"National Institute of Biomedical Imaging and Bioengineering; Ontario Institute for Cancer Research; Foundation for the National Institutes of Health","keywords":"Reporter gene; Sodium-iodide symporter; Magnetic resonance imaging; Positron emission tomography; Cancer research; Nuclear medicine; Chemistry; Medicine; Gene; Symporter; Transporter; Gene expression; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002377768,0.0001788701,0.0001795566,0.00005946622,0.0003535351,0.00003251245,0.0001398835,0.00005665529,0.00001358548],"category_scores_gemma":[0.0000058102,0.0001602455,0.00008455259,0.00007780989,0.0001683052,0.000005759601,0.0001078409,0.0001205202,3.767332e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001510393,"about_ca_system_score_gemma":0.00007705852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004471821,"about_ca_topic_score_gemma":0.000004457439,"domain_scores_codex":[0.9986424,0.00008562933,0.0002192481,0.0005585373,0.0001200819,0.0003741414],"domain_scores_gemma":[0.9995039,0.000005956468,0.00009392443,0.0002215539,0.0001019232,0.0000727769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001671173,0.00005768587,0.002319481,0.0000504336,0.00004250093,0.0001159369,0.00002007252,0.00004753748,0.9965038,0.00008032077,0.0002164208,0.0003786543],"study_design_scores_gemma":[0.002088764,0.0008025736,0.0008404751,0.0000136258,0.00006274779,0.001803742,0.0004523166,0.0008524906,0.9891446,0.00006612776,0.003439289,0.000433236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796406,0.0007241713,0.01836516,0.0006754152,0.00008366346,0.0003076135,0.00008862845,0.00002327872,0.00009147747],"genre_scores_gemma":[0.9968085,0.00001154126,0.00147799,0.000226972,0.0001593972,0.0001575538,0.001020793,0.0000287643,0.0001084986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0171679,"threshold_uncertainty_score":0.653462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105443847527218,"score_gpt":0.2586927777730287,"score_spread":0.2481483930203069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}