{"id":"W4211162951","doi":"10.1158/1078-0432.ccr-21-3385","title":"Breast Cancer Index Is a Predictive Biomarker of Treatment Benefit and Outcome from Extended Tamoxifen Therapy: Final Analysis of the Trans-aTTom Study","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Ontario Institute for Cancer Research; Cancer Research UK; BioTheranostics; Breast Cancer Research Foundation","keywords":"Tamoxifen; Medicine; Oncology; Breast cancer; Biomarker; Cancer; Internal medicine; Gynecology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01091648,0.000788687,0.00155033,0.0002054021,0.0001972992,0.0008577253,0.0008284237,0.0005882414,0.001357041],"category_scores_gemma":[0.005318258,0.0003794406,0.001968689,0.0003351561,0.0004780261,0.0005057197,0.0006941847,0.001074411,0.0002466631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307391,"about_ca_system_score_gemma":0.000440802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004768903,"about_ca_topic_score_gemma":0.000870103,"domain_scores_codex":[0.9972129,0.001953127,0.000120709,0.0002915174,0.0002880348,0.0001337823],"domain_scores_gemma":[0.9952678,0.001690083,0.0009410589,0.001292609,0.0003174026,0.0004909767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4533924,0.001388763,0.4722791,0.0006627315,0.01851721,0.0002226934,0.0002374915,0.001534943,0.008658585,0.0003551885,0.002429537,0.0403214],"study_design_scores_gemma":[0.02402904,0.04329192,0.899893,0.00007945178,0.01876233,0.0005592634,0.0001331095,0.005286347,0.003613363,0.0005436385,0.003741294,0.00006713437],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949981,0.001563712,0.001002178,0.0001183292,0.00002639138,0.000180735,0.001243112,0.00002021804,0.0008472008],"genre_scores_gemma":[0.9965034,0.0001579066,0.0007081134,0.0001010657,0.00006713432,0.0001574693,0.001881911,0.00001189801,0.0004111335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01091648,"threshold_uncertainty_score":0.05773252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1883936244206094,"score_gpt":0.4851362055094422,"score_spread":0.2967425810888328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}