{"id":"W4211171286","doi":"10.3389/falgy.2022.837463","title":"Picomolar Sensitivity Analysis of Multiple Bradykinin-Related Peptides in the Blood Plasma of Patients With Hereditary Angioedema in Remission: A Pilot Study","year":2022,"lang":"en","type":"article","venue":"Frontiers in Allergy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Université de Montréal; Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine; Université Laval","funders":"","keywords":"Hereditary angioedema; Bradykinin; Kallikrein; Prekallikrein; Chemistry; Factor XII; Internal medicine; Endocrinology; High-molecular-weight kininogen; C1-inhibitor; Kinin; Kininogen; Angioedema; Medicine; Immunology; Enzyme; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009122096,0.0002263035,0.0008845956,0.0009918719,0.00007565718,0.000005681135,0.0001900757,0.00005709712,0.00007464124],"category_scores_gemma":[0.0001591231,0.0001796493,0.0001378911,0.002578337,0.000107179,0.00009297366,0.000111595,0.0003179758,1.795867e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001001372,"about_ca_system_score_gemma":0.0001019032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002284944,"about_ca_topic_score_gemma":0.004315754,"domain_scores_codex":[0.9971721,0.0006072455,0.0007993094,0.0004143105,0.0007140009,0.0002930486],"domain_scores_gemma":[0.9987949,0.0002731784,0.0003140098,0.0004771127,0.00007676839,0.00006409877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001824584,0.006333907,0.9740183,0.00002474572,0.001285631,0.0002763483,0.00653669,0.008504269,0.00005464155,0.00001224916,0.0003758075,0.0007528248],"study_design_scores_gemma":[0.008217438,0.002395076,0.9682681,0.0000791841,0.0004303321,0.000007404298,0.006349125,0.01388413,0.00006867936,0.00002962454,0.00009935453,0.000171537],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998237,0.0004886479,0.00002836427,0.0001306023,0.0001652509,0.000750487,0.00004792856,0.00001702861,0.0001346558],"genre_scores_gemma":[0.9990822,0.00001813953,0.0004582278,0.00006048126,0.00001648627,0.00004516686,0.0001988663,0.00002469449,0.00009573667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006392853,"threshold_uncertainty_score":0.7325888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125092656848411,"score_gpt":0.2188712748465773,"score_spread":0.2076203482780932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}