{"id":"W4211171788","doi":"10.1016/j.bpj.2021.11.745","title":"Growth- and nutrient-dependent G1/S transcription factor upregulation is controlled at the transcriptional level and is critical for proliferation in poor nutrient conditions","year":2022,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"","keywords":"Downregulation and upregulation; Nutrient; Transcription factor; Cell biology; Transcription (linguistics); Chemistry; Biology; Biochemistry; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001710325,0.000494994,0.0006473409,0.0004908087,0.0004458544,0.0007670563,0.0003495032,0.0004613219,0.003729893],"category_scores_gemma":[0.0003415134,0.0004151812,0.0004299122,0.0002780087,0.0008660499,0.0005971577,0.0008882669,0.0008960466,0.001512454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001017608,"about_ca_system_score_gemma":0.0006531837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003087049,"about_ca_topic_score_gemma":0.004965837,"domain_scores_codex":[0.9997744,0.00003022734,0.00001345648,0.00006864516,0.00004435532,0.00006888538],"domain_scores_gemma":[0.9996367,0.00008598876,0.00006462256,0.00003977644,0.00005307201,0.0001199692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005118187,0.00001503837,0.000319531,0.00003157462,0.00000239327,0.00004341763,0.00002175108,0.00005462268,0.9979216,0.0001790172,0.0001547379,0.000744521],"study_design_scores_gemma":[0.00003493169,0.0001741724,0.04565309,0.00002336949,0.000008889805,0.0001927582,0.0001652386,0.0014302,0.9480345,0.0003875861,0.003876414,0.00001883144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981712,0.003990297,0.00416832,0.001181486,0.0001349576,0.00004690759,0.002609754,0.0004880301,0.005668274],"genre_scores_gemma":[0.986526,0.001094113,0.002139758,0.0002769319,0.0000526291,0.00007043567,0.002917789,0.0001825739,0.006739764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003729893,"threshold_uncertainty_score":0.0124777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02248851562714166,"score_gpt":0.2698199856504133,"score_spread":0.2473314700232717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}