{"id":"W4211177773","doi":"10.1002/ange.202002861","title":"Selective Enzymatic Oxidation of Silanes to Silanols","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Metal-Catalyzed Oxygenation Mechanisms","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dow Chemical (Canada)","funders":"Deutsche Forschungsgemeinschaft; Dow Chemical Company; National Institute of General Medical Sciences; Joan Rothenberg Family Foundation","keywords":"Chemistry; Silanes; Hydroxylation; Silane; Catalysis; Organic chemistry; Biotransformation; Disiloxane; Silanol; Monooxygenase; Cytochrome P450; Hydrogen atom abstraction; Combinatorial chemistry; Enzyme; Stereochemistry; Hydrogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008511268,0.0001519438,0.0002477707,0.00004020929,0.00003339128,0.00001710701,0.0002174646,0.00009297583,0.001487539],"category_scores_gemma":[0.0004187114,0.0001522175,0.00007197221,0.0003042994,0.00001727534,0.00009179522,0.00006141769,0.0000986435,0.0001813281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004169291,"about_ca_system_score_gemma":0.00004050538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001211959,"about_ca_topic_score_gemma":0.000003886145,"domain_scores_codex":[0.9989443,0.000009390922,0.0002935996,0.0002777186,0.0002972084,0.0001778147],"domain_scores_gemma":[0.9992433,0.00007059164,0.0001490574,0.0002350958,0.0001398221,0.0001621686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002734007,0.00002499904,0.00008018204,0.0001967547,0.00004114603,0.000002083704,0.001065,0.00001250974,0.9955339,0.0001392689,0.002661606,0.0002152484],"study_design_scores_gemma":[0.0003129522,0.00002432149,0.00003746178,0.00003173469,0.00002467966,0.000002242566,0.0002360144,0.00003145671,0.9964019,0.0002469319,0.002490537,0.0001597417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767694,0.0001062292,0.001059261,0.0008777297,0.00004037847,0.0001544663,0.0000572588,0.0001400278,0.02079524],"genre_scores_gemma":[0.9967771,0.00001028499,0.001781586,0.0004940518,0.0001464452,0.00003512274,0.0001619113,0.00002611443,0.0005673719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02022787,"threshold_uncertainty_score":0.9994252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02794672116240051,"score_gpt":0.2487936446942499,"score_spread":0.2208469235318494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}