{"id":"W4211177773","doi":"10.1002/ange.202002861","title":"Selective Enzymatic Oxidation of Silanes to Silanols","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Metal-Catalyzed Oxygenation Mechanisms","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dow Chemical (Canada)","funders":"Deutsche Forschungsgemeinschaft; Dow Chemical Company; National Institute of General Medical Sciences; Joan Rothenberg Family Foundation","keywords":"Chemistry; Silanes; Hydroxylation; Silane; Catalysis; Organic chemistry; Biotransformation; Disiloxane; Silanol; Monooxygenase; Cytochrome P450; Hydrogen atom abstraction; Combinatorial chemistry; Enzyme; Stereochemistry; Hydrogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001084085,0.0002793054,0.0001284073,0.00009503961,0.00008432614,0.0001748008,0.0001787709,0.0001582325,0.0009165442],"category_scores_gemma":[0.0001303227,0.00008402071,0.0001929915,0.0001036104,0.0001523068,0.0001441735,0.0002580278,0.000357245,0.0003188967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944694,"about_ca_system_score_gemma":0.00009886533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002464177,"about_ca_topic_score_gemma":0.0003743366,"domain_scores_codex":[0.9999292,0.000007661718,0.000003196353,0.00001822771,0.00002072173,0.00002098785],"domain_scores_gemma":[0.9999592,0.000008024371,0.00001202142,0.000006088003,0.000006204078,0.000008458903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000413038,0.00002318587,0.0005095227,0.00008416242,0.00001886346,0.00009262423,0.00002670775,0.0003766931,0.9927564,0.0006143995,0.0002298558,0.005226356],"study_design_scores_gemma":[0.000007432644,0.00006198914,0.0007591892,0.000002416292,0.000006339194,0.00009518059,0.00000970839,0.00183898,0.9946268,0.0001420265,0.002446085,0.000003819679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840171,0.001087917,0.009855811,0.0001551022,0.00004158444,0.00002155373,0.0001949978,0.000193942,0.00443184],"genre_scores_gemma":[0.9962844,0.0005066274,0.001594081,0.0000227015,0.000006289999,0.00000594535,0.0001535026,0.00001746309,0.001408994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009165442,"threshold_uncertainty_score":0.003066123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02794672116240051,"score_gpt":0.2487936446942499,"score_spread":0.2208469235318494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}