{"id":"W4211182236","doi":"10.1002/jcp.30695","title":"ERK3‐MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation","year":2022,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Jewish General Hospital; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"MyoD; C2C12; Cell biology; Myocyte; FOXO3; Skeletal muscle; Kinase; Protein kinase A; Myostatin; Signal transduction; Biology; MyoD Protein; Chemistry; Myogenesis; Endocrinology; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001082485,0.0002682556,0.0001259877,0.0001925999,0.0001876417,0.0002525224,0.0001601671,0.0001557765,0.001559815],"category_scores_gemma":[0.00007012362,0.0001218656,0.0002478855,0.0001095397,0.0002587514,0.0001652519,0.000283469,0.0003210424,0.00037855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003433597,"about_ca_system_score_gemma":0.000244741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006779746,"about_ca_topic_score_gemma":0.001575501,"domain_scores_codex":[0.9998965,0.00001018398,0.000009511647,0.00002328076,0.00002812561,0.00003238662],"domain_scores_gemma":[0.9999264,0.00000396686,0.00003102097,0.000004782466,0.000006794584,0.00002704817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001377065,0.00001345468,0.00036545,0.0000368334,0.000003670206,0.00002565649,0.000006367728,0.00003793638,0.9984524,0.0001573538,0.00003422958,0.0007289807],"study_design_scores_gemma":[0.00001684337,0.00009976067,0.0149091,0.000009735167,0.00001212745,0.0001510527,0.00002896575,0.0007893206,0.9818829,0.00008062179,0.002015543,0.000003961639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924425,0.002134043,0.002823702,0.0001243615,0.00002741851,0.00001130935,0.0005856674,0.00009965841,0.001751353],"genre_scores_gemma":[0.9958268,0.0005087082,0.001174753,0.00003581719,0.000004694919,0.000009523249,0.000283799,0.00001181259,0.00214406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559815,"threshold_uncertainty_score":0.005218148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005479121749165085,"score_gpt":0.1991913636183666,"score_spread":0.1937122418692016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}