{"id":"W4211182236","doi":"10.1002/jcp.30695","title":"ERK3‐MK5 signaling regulates myogenic differentiation and muscle regeneration by promoting FoxO3 degradation","year":2022,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Jewish General Hospital; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"MyoD; C2C12; Cell biology; Myocyte; FOXO3; Skeletal muscle; Kinase; Protein kinase A; Myostatin; Signal transduction; Biology; MyoD Protein; Chemistry; Myogenesis; Endocrinology; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003821955,0.0001178826,0.0001813249,0.00005910958,0.000250063,0.00001158084,0.0001249411,0.00008858056,0.00004978642],"category_scores_gemma":[0.00005815404,0.0001138193,0.00009831288,0.00006569022,0.00005120639,0.00001301009,0.00009528839,0.0001754016,5.29356e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000017488,"about_ca_system_score_gemma":0.00004364918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000430902,"about_ca_topic_score_gemma":0.000001607218,"domain_scores_codex":[0.9987625,0.0004073992,0.0003416673,0.0002107173,0.0001151106,0.0001625325],"domain_scores_gemma":[0.9992691,0.00002422293,0.0004452004,0.0001293906,0.00008156322,0.00005047915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001561806,0.00008492802,0.0001514009,0.00001416245,0.00005928826,7.954541e-7,0.00008128579,0.0009392531,0.9957755,0.00005858579,0.0007485414,0.001930096],"study_design_scores_gemma":[0.0008471683,0.00100421,0.00373955,0.000005876333,0.00004927802,0.00002296502,0.0001839725,0.001706673,0.9886531,0.001675417,0.001947618,0.000164187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941598,0.002274618,0.003053915,0.000189231,0.0002004101,0.0000971098,0.000006499415,0.000004438798,0.00001400238],"genre_scores_gemma":[0.9989309,0.0001248079,0.0001632217,0.0001368646,0.0002182346,0.000009677915,0.0003240696,0.00001500472,0.00007727341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007122397,"threshold_uncertainty_score":0.4641417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005479121749165085,"score_gpt":0.1991913636183666,"score_spread":0.1937122418692016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}