{"id":"W4211191046","doi":"10.3390/cancers14040878","title":"The PRP19 Ubiquitin Ligase, Standing at the Cross-Roads of mRNA Processing and Genome Stability","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Ubiquitin ligase; RNA splicing; Cell biology; DNA re-replication; Genome instability; DNA repair; Spliceosome; DNA ligase; DNA damage; DNA replication; RNA; Genetics; Ubiquitin; Computational biology; DNA; Eukaryotic DNA replication; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003629664,0.0007430826,0.0008710075,0.002200302,0.0002265557,0.0007756175,0.0006414271,0.0008095676,0.00273498],"category_scores_gemma":[0.0004379581,0.0002309885,0.00034907,0.001936437,0.0004286252,0.001024346,0.0005068709,0.001236678,0.002210251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005105158,"about_ca_system_score_gemma":0.0006907702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006167184,"about_ca_topic_score_gemma":0.001224542,"domain_scores_codex":[0.9998926,0.00001653033,0.0000140557,0.00002008494,0.00004160241,0.00001511176],"domain_scores_gemma":[0.9998172,0.0000826447,0.00002778836,0.000006683508,0.00004223164,0.00002348828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005836389,0.0000381338,0.0001959486,0.01207282,0.00006599155,0.0003393711,0.00004024699,0.0002929412,0.003831061,0.003780065,0.02431324,0.9549718],"study_design_scores_gemma":[0.000006706946,0.0000539391,0.0006225479,0.001285833,0.00004465725,0.001709786,0.00002930583,0.00004395095,0.000756554,0.001247773,0.9941872,0.00001173372],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001512759,0.9981046,0.0001564343,0.0001812114,0.0001651484,0.000002591519,0.00001668703,0.000009557959,0.001212557],"genre_scores_gemma":[0.0006269183,0.9982198,0.0001871183,0.0001182557,0.0001270579,0.000003313213,0.00003238483,0.00000151974,0.0006835594],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00273498,"threshold_uncertainty_score":0.009149432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04177726393755512,"score_gpt":0.3293085091726475,"score_spread":0.2875312452350924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}