{"id":"W4211191951","doi":"10.1016/j.bpj.2021.11.1919","title":"Combatting multidrug-resistance with membrane-active peptides","year":2022,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Efflux; Multiple drug resistance; Transmembrane protein; Transmembrane domain; Antimicrobial; Escherichia coli; Cell membrane; Chemistry; Antibiotic resistance; Membrane; Biophysics; Biology; Microbiology; Biochemistry; Antibiotics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154448,0.0002313637,0.0002467132,0.00009487879,0.0001026102,0.0004569076,0.0001285001,0.0003268633,0.0007078791],"category_scores_gemma":[0.0002075898,0.00008532568,0.000101736,0.00007040625,0.0002066113,0.0003464917,0.0002124159,0.0007689774,0.0001979126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00011354,"about_ca_system_score_gemma":0.00007685445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006514187,"about_ca_topic_score_gemma":0.00008710547,"domain_scores_codex":[0.9999483,0.00001405335,0.000003052816,0.000007037684,0.0000120736,0.00001551875],"domain_scores_gemma":[0.9999225,0.00001579803,0.00001799194,0.00000652359,0.0000108159,0.000026314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001581905,0.00005232358,0.0001494902,0.00004852144,0.00000584274,0.00009565766,0.00001610935,0.0004147258,0.9900434,0.00102021,0.0001643472,0.007831095],"study_design_scores_gemma":[0.0001080673,0.001705991,0.001748714,0.00002410061,0.00001951308,0.0007123264,0.00005642222,0.004294246,0.9770417,0.001157974,0.01311617,0.0000148001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806597,0.007055128,0.008475989,0.001070246,0.0001747091,0.00003874189,0.00007640844,0.000106489,0.002342641],"genre_scores_gemma":[0.9928496,0.002546871,0.003243363,0.0001529506,0.00003710591,0.00001253662,0.00005307694,0.00001083717,0.001093566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007078791,"threshold_uncertainty_score":0.002368033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008034922394386084,"score_gpt":0.2351039600242835,"score_spread":0.2270690376298974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}