{"id":"W4211196581","doi":"10.23977/misbp.2021036","title":"Universal CAR T cell: engineering of universal T cell, modular CAR system, and applications","year":2021,"lang":"en","type":"article","venue":"","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chimeric antigen receptor; Modular design; Computer science; Immunogenicity; T cell; Antigen; Biology; Immune system; Immunology; Operating system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000359049,0.0004560192,0.0002745743,0.0005567282,0.0003251019,0.0005892717,0.000439713,0.0007233949,0.002028508],"category_scores_gemma":[0.0002263286,0.000241749,0.0004356002,0.000428392,0.0003398429,0.0006561164,0.0005666736,0.0006467375,0.0008752701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004473156,"about_ca_system_score_gemma":0.0005546057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000522617,"about_ca_topic_score_gemma":0.0004323515,"domain_scores_codex":[0.9997136,0.00003691701,0.00001726601,0.00007194501,0.000100203,0.00006005169],"domain_scores_gemma":[0.9999176,0.00000826677,0.00001749922,0.00001037597,0.00002596035,0.00002016896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001520275,0.00009420745,0.0009273952,0.0005739873,0.00002384301,0.0004719934,0.0002505236,0.00481872,0.8525769,0.03377996,0.003900268,0.1024302],"study_design_scores_gemma":[0.00004492438,0.00106069,0.00107872,0.0000601314,0.00006541291,0.002560055,0.0001274952,0.01925027,0.7672845,0.004041286,0.2043592,0.00006737732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2619728,0.02156746,0.6668019,0.001353403,0.001070783,0.0006337386,0.0006085748,0.002221277,0.04377018],"genre_scores_gemma":[0.7345363,0.009392362,0.2313468,0.0005592525,0.0001885824,0.0005153542,0.0006790804,0.0002052766,0.02257686],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002028508,"threshold_uncertainty_score":0.006785989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009362667109904795,"score_gpt":0.2306318754622036,"score_spread":0.2212692083522988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}