{"id":"W4211197716","doi":"10.1016/j.bpj.2021.11.2187","title":"The ACTC A331P hypertrophic cardiomyopathy mutation enhances basal contractile activity and causes resting muscle dysfunction","year":2022,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Hypertrophic cardiomyopathy; Actin; Mutation; Pathogenesis; Contraction (grammar); Biology; Internal medicine; Cardiology; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002498509,0.0008115638,0.0003217704,0.0005425765,0.000370554,0.0003003594,0.000392305,0.001388407,0.003463739],"category_scores_gemma":[0.0006059994,0.0002472143,0.0003238296,0.0002950609,0.0007649193,0.0002218932,0.0003954743,0.0009005059,0.000713492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885981,"about_ca_system_score_gemma":0.0002125809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000700413,"about_ca_topic_score_gemma":0.0008126833,"domain_scores_codex":[0.9996856,0.00007300489,0.00004079424,0.00005490324,0.00008903257,0.00005672666],"domain_scores_gemma":[0.9993371,0.0002732339,0.0001058189,0.00005198716,0.00003888886,0.0001929928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003446589,0.0001041924,0.002040773,0.00003575473,0.00001661608,0.00685789,0.00007077539,0.0001368996,0.987491,0.0001901472,0.0002741605,0.00243714],"study_design_scores_gemma":[0.0003272475,0.0023491,0.1728896,0.00009391821,0.0001910995,0.0695658,0.0004141819,0.005899635,0.7417274,0.0008464779,0.005602374,0.00009311848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959252,0.0003713822,0.00121059,0.0002516293,0.00008286097,0.00002005555,0.0003851104,0.00009362454,0.001659581],"genre_scores_gemma":[0.9979929,0.0001334522,0.0004624403,0.0001088069,0.00002771175,0.00002111136,0.000223664,0.00004689566,0.0009830194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003463739,"threshold_uncertainty_score":0.01158738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718441848413076,"score_gpt":0.2603709310191836,"score_spread":0.2431865125350529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}