{"id":"W4211198732","doi":"10.3390/nu14030701","title":"The Dietary Supplement Creatyl-l-Leucine Does Not Bioaccumulate in Muscle, Brain or Plasma and Is Not a Significant Bioavailable Source of Creatine","year":2022,"lang":"en","type":"article","venue":"Nutrients","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Creatine; Creatine Monohydrate; Bioavailability; Creatine kinase; Metabolite; Leucine; Internal medicine; Phosphocreatine; Endocrinology; Biochemistry; Medicine; Chemistry; Pharmacology; Energy metabolism; Amino acid; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001466444,0.0006445238,0.0007181632,0.0005025058,0.0003229059,0.0003863406,0.0005341761,0.0008717298,0.003073923],"category_scores_gemma":[0.0002261903,0.0001981094,0.000306369,0.0002691757,0.0005067362,0.0004956784,0.0002417838,0.0009176692,0.0007022558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003997605,"about_ca_system_score_gemma":0.0005956196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001687665,"about_ca_topic_score_gemma":0.00327889,"domain_scores_codex":[0.9995959,0.00005424807,0.00004071619,0.00009718693,0.0001381219,0.000073773],"domain_scores_gemma":[0.9994652,0.00004912804,0.0001714616,0.00006575174,0.0001154261,0.0001330141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004555332,0.0004418264,0.0002261824,0.0002531379,0.00002842513,0.00009477909,0.00003429308,0.00005389283,0.9896646,0.00009201008,0.00008954235,0.004465884],"study_design_scores_gemma":[0.0001957796,0.005648201,0.002165615,0.00003339462,0.00007214249,0.0002494658,0.00006921723,0.0002548159,0.9847968,0.00004315621,0.006448422,0.00002297647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905463,0.003161154,0.002018015,0.0001940635,0.0001136386,0.0001829575,0.0008244265,0.0001622145,0.002797283],"genre_scores_gemma":[0.9776177,0.001989912,0.005821703,0.000178266,0.00003621938,0.0003277978,0.001144035,0.00005788072,0.0128264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003073923,"threshold_uncertainty_score":0.01028335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01755751585291463,"score_gpt":0.2564947633035196,"score_spread":0.238937247450605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}