{"id":"W4211201593","doi":"10.1016/j.psj.2022.101775","title":"Broiler chickens with 1950s genetics display a stable immune profile as measured by Kinome, mRNA expression, and metabolism when stimulated early in life with CpG","year":2022,"lang":"en","type":"article","venue":"Poultry Science","topic":"Aquaculture disease management and microbiota","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Evonik Industries","keywords":"Immune system; Broiler; Biology; Gene knockdown; Kinome; TLR9; PI3K/AKT/mTOR pathway; Immunology; Genetics; Gene expression; Gene; Signal transduction; DNA methylation; Animal science","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009568762,0.0002954114,0.0001827374,0.0004640966,0.0002332146,0.0002212054,0.0001004284,0.0002211704,0.001170484],"category_scores_gemma":[0.00009326067,0.0001902881,0.000130075,0.000148581,0.0003444978,0.00009523665,0.0001801544,0.0003923704,0.0002302126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00055862,"about_ca_system_score_gemma":0.0002409241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007743467,"about_ca_topic_score_gemma":0.02925467,"domain_scores_codex":[0.9998304,0.00001157621,0.00001035082,0.00006454656,0.00004843266,0.00003469258],"domain_scores_gemma":[0.9997843,0.00001420222,0.00009146937,0.0000140962,0.00003373333,0.00006232465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002049881,0.00002814108,0.003676089,0.00001829637,0.000008104168,0.00004721648,0.00004221505,0.00002076383,0.9947791,0.0000393908,0.00003497702,0.001100695],"study_design_scores_gemma":[0.00003828211,0.001101296,0.7687824,0.0000224561,0.0000556316,0.0007285562,0.0003472446,0.0003648976,0.2238075,0.00007412086,0.004651069,0.00002654394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979686,0.000257213,0.0005427655,0.0000377923,0.000009843923,0.000009985714,0.0003154001,0.00002235588,0.0008359856],"genre_scores_gemma":[0.9915319,0.0002812536,0.002042959,0.00007594757,0.000009328371,0.00003154267,0.0006830398,0.00002958184,0.005314426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007743467,"threshold_uncertainty_score":0.01539683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006006986305423221,"score_gpt":0.2006464406684016,"score_spread":0.1946394543629784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}