{"id":"W4211201593","doi":"10.1016/j.psj.2022.101775","title":"Broiler chickens with 1950s genetics display a stable immune profile as measured by Kinome, mRNA expression, and metabolism when stimulated early in life with CpG","year":2022,"lang":"en","type":"article","venue":"Poultry Science","topic":"Aquaculture disease management and microbiota","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Evonik Industries","keywords":"Immune system; Broiler; Biology; Gene knockdown; Kinome; TLR9; PI3K/AKT/mTOR pathway; Immunology; Genetics; Gene expression; Gene; Signal transduction; DNA methylation; Animal science","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003780636,0.0002564079,0.0002995031,0.0001809198,0.0006965107,0.00008548133,0.0005575016,0.00007068876,0.0007180527],"category_scores_gemma":[0.00004540315,0.0001815539,0.00002743361,0.0007100243,0.000627118,0.0002970125,0.000392236,0.0003837732,0.000045785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004413849,"about_ca_system_score_gemma":0.000247781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000378013,"about_ca_topic_score_gemma":0.00001550215,"domain_scores_codex":[0.9981542,0.0001496198,0.000251707,0.000660315,0.0001885726,0.0005956476],"domain_scores_gemma":[0.9992433,0.0000279189,0.0001514531,0.0003815215,0.0001061907,0.00008967401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005295153,0.0002251582,0.03751546,0.00001491438,0.00006366916,0.00001291645,0.002168604,0.0001025952,0.9555517,0.0001699968,0.003435334,0.0002101038],"study_design_scores_gemma":[0.01441425,0.001158898,0.6315394,0.0002005505,0.0003695327,0.000165578,0.01057643,0.0001135374,0.198808,0.0001573063,0.1405142,0.001982245],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909326,0.007036809,0.00007911208,0.000192263,0.0001381403,0.0006122869,0.0001429899,0.00005555564,0.0008101965],"genre_scores_gemma":[0.9931943,0.00002944778,0.0002705175,0.0002635121,0.000008255763,0.0001150518,0.0001530574,0.00002040439,0.005945425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7567437,"threshold_uncertainty_score":0.7862173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006006986305423221,"score_gpt":0.2006464406684016,"score_spread":0.1946394543629784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}