{"id":"W4211212229","doi":"10.1126/stke.2962005re10","title":"14-3-3 Proteins: A Number of Functions for a Numbered Protein","year":2005,"lang":"en","type":"review","venue":"Science s STKE","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Phosphoserine; Computational biology; Phosphopeptide; Human proteins; Scaffold protein; Biology; Signal transduction; Cell biology; Genetics; Phosphorylation; Serine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005985691,0.0003727876,0.000683169,0.0001712322,0.0002778213,0.00006743886,0.0008361149,0.0003287238,0.0001810144],"category_scores_gemma":[0.0007835698,0.0003216204,0.000564114,0.0006956818,0.0006044765,0.00002043811,0.0002538415,0.0002426503,0.0001555893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001035199,"about_ca_system_score_gemma":0.001740517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002716095,"about_ca_topic_score_gemma":0.00004155446,"domain_scores_codex":[0.9975282,0.00006974016,0.0006273297,0.0008835507,0.0003701398,0.000521064],"domain_scores_gemma":[0.9978682,0.00002290523,0.0005227115,0.0009424147,0.0004997015,0.0001440088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003473049,0.0002740343,0.000003235675,0.003526411,0.0001491821,9.419832e-7,0.0000305527,0.000002357954,0.02058835,0.0006188328,0.002863229,0.9719082],"study_design_scores_gemma":[0.0001857294,0.0001619034,8.281392e-7,0.001878243,0.0001188764,0.00006321742,0.00002096768,0.000003275564,0.003889566,0.00007678683,0.9932604,0.0003402091],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000228997,0.9782507,0.003887564,0.00006590103,0.0006513727,0.007868002,0.0006048025,0.00004548947,0.00839721],"genre_scores_gemma":[0.0006664182,0.9208179,0.02833747,0.00005197906,0.00141135,0.01143906,0.000391002,0.0001565115,0.03672832],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9903972,"threshold_uncertainty_score":0.9999236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03894834875801342,"score_gpt":0.3906932339411026,"score_spread":0.3517448851830891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}