{"id":"W4211213088","doi":"10.1016/j.jbc.2022.101716","title":"A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"AGADA Biosciences; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Choline; Choline kinase; Kinase; Internal medicine; Cardiac arrhythmia; Medicine; Biology; Endocrinology; Genetics; Cardiology; Atrial fibrillation; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004157365,0.002460519,0.0006112861,0.003156923,0.0007544365,0.0006438252,0.001063811,0.002539928,0.008463691],"category_scores_gemma":[0.0002969027,0.0007259754,0.001150838,0.001121056,0.0008124316,0.000694998,0.0008238758,0.002947377,0.002033122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004709718,"about_ca_system_score_gemma":0.0003919114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000762023,"about_ca_topic_score_gemma":0.001213732,"domain_scores_codex":[0.9992706,0.00009154817,0.0001203903,0.0002023064,0.0002048679,0.0001102593],"domain_scores_gemma":[0.9991044,0.0001332467,0.0003610508,0.00007006152,0.00005352657,0.0002776987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005147606,0.0003201697,0.0004782935,0.00008718538,0.00005275614,0.001600821,0.00005282904,0.0001211025,0.9943572,0.0008762805,0.0004428192,0.001095855],"study_design_scores_gemma":[0.0007567183,0.001790885,0.01353149,0.0001521608,0.0004792096,0.01945709,0.0002990393,0.003100297,0.9395164,0.001109068,0.01972074,0.00008699892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653652,0.00223434,0.01559825,0.001388662,0.0004358376,0.0003371215,0.007312827,0.001304002,0.006023924],"genre_scores_gemma":[0.935949,0.003846181,0.01433461,0.0005997443,0.0001271311,0.0007321859,0.007660207,0.0004776672,0.03627329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008463691,"threshold_uncertainty_score":0.02831382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01944911538620491,"score_gpt":0.2323125106367083,"score_spread":0.2128633952505034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}