{"id":"W4211260249","doi":"10.3324/haematol.2021.279486","title":"A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells <i>in vitro</i> and <i>in vivo</i>","year":2022,"lang":"en","type":"article","venue":"Haematologica","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"David och Astrid Hageléns Stiftelse; Barncancerfonden; Vetenskapsrådet; Cancerfonden","keywords":"CD34; Stem cell; CD38; Myeloid leukemia; Cancer research; Haematopoiesis; Leukemia; In vivo; Myeloid; Ex vivo; Transplantation; Immunology; Biology; Medicine; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101214,0.000433367,0.000178406,0.00017585,0.00007220014,0.0001821574,0.0002186497,0.0003059722,0.0009346526],"category_scores_gemma":[0.0001078905,0.0001181522,0.0001528386,0.0001316183,0.0001251865,0.0001454921,0.0002416965,0.0005284653,0.0003201704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001538494,"about_ca_system_score_gemma":0.000153181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002253671,"about_ca_topic_score_gemma":0.0003939981,"domain_scores_codex":[0.9998411,0.00002483423,0.00001055138,0.00003269462,0.0000523113,0.00003837593],"domain_scores_gemma":[0.9999591,0.000005165501,0.0000136657,0.000004072809,0.00000418683,0.00001377882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007575867,0.00006481435,0.00007339247,0.00002489613,0.000004664164,0.00003205103,0.000006553732,0.000242951,0.995815,0.0001115985,0.00009430199,0.003454058],"study_design_scores_gemma":[0.00004630967,0.0009711235,0.001084096,0.000004008378,0.00001880886,0.0003605461,0.000007173831,0.002873286,0.9905164,0.00005208102,0.004059833,0.000006425891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713897,0.001494408,0.02354548,0.0001646888,0.00003269748,0.0001727254,0.0003166039,0.0004121631,0.002471552],"genre_scores_gemma":[0.9869974,0.0006279593,0.008896175,0.0001255219,0.00001056401,0.00008162261,0.0005495167,0.00002815142,0.002683058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009346526,"threshold_uncertainty_score":0.00312674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02402904383263815,"score_gpt":0.2501588229318998,"score_spread":0.2261297790992617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}