{"id":"W4211260249","doi":"10.3324/haematol.2021.279486","title":"A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells <i>in vitro</i> and <i>in vivo</i>","year":2022,"lang":"en","type":"article","venue":"Haematologica","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"David och Astrid Hageléns Stiftelse; Barncancerfonden; Vetenskapsrådet; Cancerfonden","keywords":"CD34; Stem cell; CD38; Myeloid leukemia; Cancer research; Haematopoiesis; Leukemia; In vivo; Myeloid; Ex vivo; Transplantation; Immunology; Biology; Medicine; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002784475,0.001132025,0.002343169,0.001318494,0.000772151,0.0002109785,0.0009465398,0.0006083647,0.003305344],"category_scores_gemma":[0.0001295443,0.00104625,0.0004144948,0.001755391,0.000845565,0.0002203931,0.001272627,0.002051073,0.0001543734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00165537,"about_ca_system_score_gemma":0.0006619863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003227347,"about_ca_topic_score_gemma":0.0001209126,"domain_scores_codex":[0.9909815,0.001028559,0.001596494,0.002348015,0.001821183,0.002224285],"domain_scores_gemma":[0.9951641,0.001814091,0.0004686693,0.001589826,0.000196999,0.0007663009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002491918,0.0008337391,0.0004573257,0.0003758966,0.0001593398,0.002972561,0.001907989,0.0001510582,0.9784522,0.001232513,0.00781035,0.003155096],"study_design_scores_gemma":[0.02123173,0.00210757,0.003882397,0.0003846399,0.0003147307,0.004991431,0.001082971,0.006116531,0.5095299,0.0001877262,0.4479724,0.002197945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673061,0.01673334,0.0001476526,0.0005543096,0.0004454892,0.002965268,0.0002859309,0.0003132874,0.01124865],"genre_scores_gemma":[0.9752247,0.005133606,0.001389847,0.0006088211,0.0001579628,0.0007085236,0.00009009002,0.0002272764,0.01645912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4689223,"threshold_uncertainty_score":0.9991988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02402904383263815,"score_gpt":0.2501588229318998,"score_spread":0.2261297790992617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}